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Viral Infection of the Central Nervous System

Many viruses causing infection of the central nervous system (CNS) are covered in chapters devoted to each type of virus. For example, enteroviruses, the agents most frequently causing meningitis and occasionally encephalitis, are covered in site. The herpes viruses that cause meningitis, encephalitis, or both, especially herpes simplex virus (HSV), varicella-zoster virus (VZV), and Epstein-Barr virus (EBV), are discussed in site. This SITEconsiders viruses that cause CNS diseases (Box 1) as their primary manifestations. Arthropod-Borne Viral Encephalitis LYMPHOCYTIC CHORIOMENINGITIS (LCM) Lymphocytic choriomeningitis (LCM) virus is an arenavirus, the same family as Lassa virus. All arenaviruses have a common reservoir in animals, especially small rodents. The infected animals may be asymptomatic or […]

Creutzfeldt-Jakob Disease

Essentials of Diagnosis Progressive mentation abnormalities leading to disorders of gait and myoclonus. Occurs in sixth and seventh decades in previously normal patients. May be history of corneal transplant, neurosurgical procedures, or use of human growth hormone. Characteristic brain biopsy abnormalities of spongiform degeneration, neuron loss, and astrogliosis. General Considerations Creutzfeldt-Jakob disease is a progressive, fatal illness of the central nervous system that is seen most frequently in the sixth and seventh decades of life. The disease is sporadic and found worldwide, with an incidence of disease of 1 case/million people per year. The mode of acquisition is unknown, but a higher incidence of the disease among Israelis of Libyan origin […]

Rabies

Essentials of Diagnosis Subacute onset of neurologic abnormalities including hallucinations, combativeness, muscle spasms, seizures, and focal paralysis. Detection of negri bodies or rabies antigen in animal or human brain tissue (70-90%). Rabies-neutralizing antibody in serum or CSF diagnostic in an unimmunized patient. General Considerations Rabies is an acute fatal viral illness of the CNS. It can affect all mammals and is transmitted between them by infected secretions, most often by bite. It was first recognized more than 3000 years ago and has been among the most feared of infectious diseases. It is said that Aristotle recognized that rabies could be spread by a rabid dog. Epidemiology Rabies exists in two epizooic […]

Arthropod-Borne Viral Encephalitis

Essentials of Diagnosis Summer and fall cases, especially if in a cluster or outbreak, suggest arboviruses or enteroviruses. History of exposure to mosquitoes suggests arbovirus infection, especially in geographic areas of high endemicity (eg, swamps of Florida). Maculopapular rash suggests enterovirus disease. Lymphocytic pleocytosis in cerebrospinal fluid (CSF) with normal glucose and protein concentrations suggests viral meningitis. General Considerations Arthropod-borne (arbo) viruses causing encephalitis are members of the toga-, flavi-, and bunyavirus families. The medically important togaviruses include rubella virus, which is discussed in site, and the equine encephalitis viruses. The flavivirus family, which includes St. Louis encephalitis (SLE) and West Nile viruses, also includes dengue and yellow fever viruses; the […]

Parvoviruses

Essentials of Diagnosis Erythema infectiosum: "slapped cheek" rash in a child. Aplastic crisis in patients with chronic hemolytic anemia or AIDS. Giant pronormoblasts seen in bone marrow. Specific antibody (immunoglobulin G [IgG] and IgM), although these may not develop in certain immunocompromised patients. Detection of specific nucleic acids (eg, by polymerase chain reaction [PCR] assay) or antigens in blood. General Considerations Parvoviruses are widespread bird and mammalian viruses. More than 50 types have been identified, but the most common identified human pathogen is parvovirus B19. It is the cause of erythema infectiosum (Fifth disease) and is responsible for episodes of aplastic crises in patients with chronic anemia, especially those with hemolytic […]

Poxviruses

Essentials of Diagnosis Multiple, large, eosinophilic cytoplasmic inclusions in epithelial cells (H & E stain). Vesicular or nodular skin lesions. Exposure by occupation or close personal contact. High index of suspicion in patients with skin lesions and exposure to sheep, goats, or cows. General Considerations Poxviruses are a large, complex family of viruses that cause disease in humans and other animals (Table 1). Of the many genera in this family, only species of Orthopoxvirus and Molluscipoxvirus are associated specifically with humans. The former contains variola virus (smallpox), which is currently of historical interest only, and the latter molluscum contagiosum virus. Poxviruses in other genera naturally infect animals (zoonoses) but cause incidental […]

HIV & Other Retroviruses

Essentials of Diagnosis Human immunodeficiency virus (HIV) RNA is detected and quantitated by polymerase chain reaction or branched DNA methods. Major diagnostic clues to HIV infection are a low CD4 lymphocyte count or an unexplained opportunistic infection. Human T-lymphotropic virus type 1 (HTVL-1) infection should be suspected in an adult patient with a T-cell malignancy or spastic paraparesis who is from Japan or the Caribbean basin. General Considerations Epidemiology Two major groups of retroviruses are considered in this chapter: the oncoviruses ("onco-," related to a tumor) and the lentiviruses ("lenti-," slow). Oncoviruses have long been associated with a variety of cancers in animals, including leukemia, lymphoma, and sarcoma; however, until recent […]

Clarithromycin 125mg/5ml Oral Suspension

Generic Name: Clarithromycin Information For The User What Clarithromycin 125mg/5ml Oral Suspension Is And What It Is Used For Clarithromycin 125mg/5ml oral suspension contains clarithromycin. Clarithromycin belongs to a group of antibiotics called macrolides. Clarithromycin works by destroying some types of bacteria that cause certain infections. Clarithromycin may be used to treat infections that are caused by bacteria in the chest, throat, sinuses and ear and infections of the skin and the layers of flesh just under the skin. Clarithromycin 125mg/5ml oral Suspension is used in children 6 months to 12 years old. Before You Give Clarithromycin 125mg/5ml Oral Suspension Do not give Clarithromycin 125mg/5ml Oral Suspension to your child: If your […]

Clarithromycin 250mg, 500mg Tablets [US: Biaxin]

Generic Name:¬†Clarithromycin Under what local brands and in what dosages is generic Fluconazole sold in pharmacies of Britain, United States, and Canada? In pharmacies of the United States, Great Britain and Canada the pharmacists offer you to buy Fluconazole according to your prescription or without a prescription under such brand names and in such strengths and dosage forms: UK US Canada Clarithromycin 250mg Tablets Clarithromycin 500mg Tablets Klaricid 250 mg Tablets Klaricid 500 mg Tablets Clarithromycin 250mg Tablets Clarithromycin 500mg Tablets Biaxin 250 mg Tablets Biaxin 500 mg Tablets Clarithromycin 250mg Tablets Clarithromycin 500mg Tablets Biaxin 250 mg Tablets Biaxin 500 mg Tablets Patient Information On Clarithromycin 250mg Film-coated Tablets Clarithromycin […]

Fluconazole 50mg, 100mg, 150mg, 200mg Capcules

Generic Name: Fluconazole Under what local brands and in what dosages is generic Fluconazole sold in pharmacies of Britain, United States, and Canada? In pharmacies of the United States, Great Britain and Canada the pharmacists offer you to buy Fluconazole according to your prescription or without a prescription under such brand names and in such strengths and dosage forms: UK US Canada Azocan 50mg Capsules Azocan 100mg Capsules Azocan 150mg Capsules Azocan-P 150mg Capsules Boots Thrush 150mg Capsule Diflucan 150 Capsules Fluconazole 50mg Capsules Fluconazole 100mg Capsules Fluconazole 150mg Capsules Fluconazole 200mg Capsules Diflucan 50mg Tablets Diflucan 100mg Tablets Diflucan 150 mg Tablets Diflucan 200 mg Tablets Fluconazole 50mg Tablets Fluconazole […]

Dosage forms of Zidovudine:
Retrovir iv infusion vial Retrovir 100 mg capsule Zidovudine 300 mg tablet Retrovir 300 mg tablet
Retrovir 50 mg/5ml Syrup 240ml Bottle      

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Therapeutic classes of Zidovudine:

Anti-HIV Agents, Antimetabolites, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors, Reverse Transcriptase Inhibitors

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