Tags: Tazicef

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative …

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Ceftazidime

• Ceftazidime is a semisynthetic, third generation cephalosporin antibiotic. Uses Ceftazidime is used for the treatment of bone and joint infections, intra-abdominal and gynecologic infections, meningitis and other CNS infections, lower respiratory tract infections, skin and skin structure infections, and complicated or uncomplicated urinary tract infections caused by susceptible bacteria. The drug also is used for empiric anti-infective agent therapy in febrile neutropenic patients and has been used for perioperative prophylaxis. Ceftazidime therapy may be started pending results of susceptibility tests, but should be discontinued if the organism is found to be resistant to the drug. When the causative organism is unknown, concomitant therapy with another anti-infective agent may be indicated …

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