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Paracoccidioidomycosis

Essentials of Diagnosis Patients usually immunocompetent. Patients in endemic areas with chronic pulmonary and mucotaneous lesions involving the mouth, nose, larynx, and face; regional or diffuse lymphadenopathy. Found in Latin America, from Mexico to Argentina. Dimorphic fungus: yeast form in tissue specimens and at 37 °C; mold form when grown at room temperature in the laboratory. Thick-walled yeast, 4-40 um, with multiple buds when seen in tissue specimens. Complement fixation or immunodiffusion. General Considerations Paracoccidioidomycosis is caused by Paracoccidioides brasiliensis. Also known as South American blastomycosis, it is the most prevalent systemic mycosis found in Central and South America and is the most common endemic mycosis in this area. A. Epidemiology. …

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