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Norfloxacin is authorised in the world under the following brand names: Chibroxin, Noroxin.

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Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative […]

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Norfloxacin Norfloxacin is a fluoroquinolone anti-infective agent. Dosage and Administration Administration Norfloxacin is administered orally. The drug should be given with a glass of water at least 1 hour before or at least 2 hours after a meal or ingestion of milk or other dairy products. Patients receiving norfloxacin should be well hydrated and should be instructed to drink fluids liberally. To minimize the possibility of interference with the GI absorption of norfloxacin, patients should be instructed not to ingest antacids containing magnesium or aluminum, sucralfate, metal cations such as iron or zinc (including multivitamin preparations containing zinc), or buffered didanosine preparations concomitantly with or within 2 hours of a norfloxacin […]

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Norfloxacin: Drug Interactions Antacids Antacids containing magnesium hydroxide or aluminum hydroxide may decrease absorption of oral norfloxacin, and the drugs probably should not be administered concomitantly. Patients should be instructed not to ingest antacids concomitantly with or within 2 hours of a norfloxacin dose. The mechanism of this interaction has not been fully elucidated to date, but studies using ciprofloxacin indicate that antacids containing magnesium and aluminum ions may bind to, and form insoluble complexes with, quinolones in the GI tract.  Antifungal Agents Norfloxacin is inactive against fungi when used alone, but results of some in vitro studies using Candida suggest that the drug may enhance the antifungal activity of antifungal […]

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Norfloxacin: Cautions Oral norfloxacin is generally well tolerated at dosages used in the treatment of urinary tract infections, and adverse effects of the drug are similar to those reported with other quinolone anti-infectives (e.g., ciprofloxacin, ofloxacin). Adverse effects have been reported in about 3.5-10% of patients receiving norfloxacin and have been severe enough to require discontinuance in 1% or less of patients. The most frequent adverse effects of the drug reported during clinical trials involved the GI tract or CNS; however, the adverse effect most frequently reported in postmarketing experience is rash. Adverse effects have occurred in about 7% of patients receiving a single 800-mg oral dose of norfloxacin for the […]

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Norfloxacin: Uses Norfloxacin is used in adults for the treatment of complicated and uncomplicated urinary tract infections and prostatitis caused by susceptible organisms and for the treatment of uncomplicated gonorrhea. Norfloxacin also has been used in adults for the treatment of various GI infections caused by susceptible organisms. Because only low serum concentrations of norfloxacin are attained after oral administration of usual dosages, use of the drug is generally limited to genitourinary or GI tract infections. Prior to initiation of norfloxacin therapy, appropriate specimens should be obtained for identification of the causative organism and in vitro susceptibility tests. Norfloxacin may be initiated, however, before obtaining the results of these tests. If […]

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Levofloxacin (Levaquin): Compare to Other Antibiotics Generic Name: Levofloxacin Under what local brands and in what dosages is generic Levofloxacin sold in pharmacies of Britain, United States, and Canada? In pharmacies of the United States, Great Britain and Canada the pharmacists offer you to buy Levofloxacin according to your prescription or without a prescription under such brand names and in such strengths and dosage forms: UK US Canada Evoxil 250mg film-coated tablets Evoxil 500mg film-coated tablets Evoxil 5mg/ml solution for infusion Levofloxacin 250mg Tablets Levofloxacin 500mg Tablets Levofloxacin 5mg/ml Solution for Infusion Tavanic I.V. 5 mg/ml Tavanic 250 mg Tablets Tavanic 500 mg Tablets Levaquin 250 mg Tablets Levaquin 500 mg […]

Dosage forms of Norfloxacin:
Co Norfloxacin 400 mg Tablet Novo-Norfloxacin 400 mg Tablet Pms-Norfloxacin 400 mg Tablet Apo-Norflox 400 mg Tablet
Noroxin 400 mg tablet      

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Therapeutic classes of Norfloxacin:

Anti-Bacterial Agents, Anti-Infectives, Enzyme Inhibitors, Nucleic Acid Synthesis Inhibitors, Quinolones

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