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Enterococci

Essentials of Diagnosis • Gram stain shows gram-positive cocci that occur in singles, pairs, and short chains; recovery of microorganism from culture of blood or other sterile source. • Lancefield group D antigen. • Clinical isolates: Enterococcus faecalis, 74%; E faecium, 16%; other species, 10%. • Facultative anaerobes grow in 6.5% NaCl at pH 9.6 and at temperatures ranging from 10 °C to 45 °C, and grow in the presence of 40% bile salts and hydrolyze esculin and L-pyrrolidonyl-ß-naphthylamide. • Infections typically of a gastrointestinal or genitourinary origin. • The most common infections are urinary tract infection, bacteremia, endocarditis, intra-abdominal and pelvic infection, and wound and soft tissue infection. General Considerations …

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Enterococci: Clinical Syndromes

URINARY TRACT INFECTION Urinary tract infections, including uncomplicated cystitis, pyelonephritis, prostatitis, and perinephric abscess, are the most common type of clinical infections produced by enterococci (Box 1). Most enterococcal urinary tract infections are nosocomial and are associated with urinary catheterization or instrumentation. BACTEREMIA & ENDOCARDITIS Nosocomial enterococcal bacteremias are commonly polymicrobial. Portals of entry for enterococcal bacteremia include the urinary tract, intra-abdominal or pelvic sources, wounds (especially burns, decubitus ulcers, and diabetic foot infections), intravascular catheters, and the biliary tree. Metastatic infections other than endocarditis are rare in enterococcal bacteremia. Enterococci account for ~5-10% of all cases of infective endocarditis (see site). Most cases are caused by E faecalis, but E …

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Norfloxacin: Side Effects

See also Fluoroquinolones Norfloxacin is a fluoroquinolone antibacterial drug with properties similar to those of ciprofloxacin, although less potent in vitro. Norfloxacin inhibits CYP1A2 and can therefore enhance the effects of other drugs by reducing their clearance. Comparative studies In a double-blind, multicenter study 171 patients who had acute pyelonephritis were given intravenous cefuroxime for 2-3 days, followed by ceftibuten 200 mg bd or norfloxacin 400 mg bd for 10 days. There were fewer bacterial relapses after oral norfloxacin than ceftibuten. Adverse events were reported by 47% of the patients taking ceftibuten and by 38% of those taking norfloxacin. This difference was not significant, but diarrhea or loose stools occurred more …

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Urinary Tract Infections and Prostatitis

Definition Infections of the urinary tract represent a wide variety of clinical syndromes including urethritis, cystitis, prostatitis, and pyelonephritis. A urinary tract infection is defined as the presence of microorganisms in the urine that cannot be accounted for by contamination. The organisms have the potential to invade the tissues of the urinary tract and adjacent structures. Lower tract infections include cystitis (bladder), urethritis (urethra), prostatitis (prostate gland), and epididymitis. Upper tract infections involve the kidney and are referred to as pyelonephritis. Uncomplicated urinary tract infections are not associated with structural or neurologic abnormalities that may interfere with the normal flow of urine or the voiding mechanism. Complicated urinary tract infections are …

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Syphilis

The causative organism of syphilis is Treponema pallidum, a spirochete. Syphilis is usually acquired by sexual contact with infected mucous membranes or cutaneous lesions, although on rare occasions it can be acquired by nonsexual personal contact, accidental inoculation, or blood transfusion. Clinical presentation The clinical presentation of syphilis is varied, with progression through multiple stages possible in untreated or inadequately treat patients (Table Presentation of Syphilis Infections). Primary Syphilis Primary syphilis is characterized by the appearance of a chancre on cutaneous or mucocutaneous tissue. Chancres persist only for 1 to 8 weeks before spontaneously disappearing. TABLE. Treatment of Gonorrhea Type of Infection Recommended Regimensa Alternative Regimensb Uncomplicated infections of the cervix, …

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Bacterial Infections

The bacterial species most commonly associated with gastrointestinal infection and infectious diarrhea in the United States are Shigella spp., Salmonella spp., Campylobacter spp., Yersinia spp., Escherichia spp., Clostridium spp., and Staphylococcus spp. Antibiotics are not essential in the treatment of most mild diarrheas, and empirical therapy for acute gastrointestinal infections may result in unnecessary antibiotic courses. Enterotoxigenic (cholera-like) Diarrhea Cholera (Vibrio cholerae) Vibrio cholerae is the organisms that most often causes human epidemics and pandemics. Four mechanisms for transmission have been proposed: animal reservoirs, chronic carriers, asymptomatic or mild disease victims, or water reservoirs. TABLE. Clinical Assessment of Degree of Dehydration in Children Based on Percentage of Body Weight Lossa Variable …

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Invasive (dysentery-like) Diarrhea

Bacillary Dysentery (Shigellosis) Four species of Shigella are most often associated with disease: S. dysenteriae type I, S. flexneri, S. bovdii, and S. sonnei. Poor sanitation, poor personal hygiene, inadequate water supply, malnutrition, and increased population density are associated with increased risk of Shigella gastroenteritis epidemics, even in developed countries. The majority of cases are thought to result from fecal-oral transmission. Shigella spp. cause dysentery upon penetrating the epithelial cells lining the colon. Microabscesses may eventually coalesce, forming larger abscesses. Some Shigella species produce a cytotoxin, or shigatoxin, the pathogenic role of which is unclear although it is thought to damage endothelial cells of the lamina propria, resulting in microangiopathic changes …

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Antimicrobial Regimen Selection

Introduction A generally accepted systematic approach to the selection and evaluation of an antimicrobial regimen is shown in Table Systematic Approach for Selection of Antimicrobials. An «empiric» antimicrobial regimen is begun before the offending organism is identified, while a «definitive» regimen is instituted when the causative organism is known. Confirming the presence of infection Fever Fever is defined as a controlled elevation of body temperature above the normal range of 36.7 to 37.0В°C. Fever is a manifestation of many disease states other than infection. Many drugs have been identified as causes of fever. Drug-induced fever is defined as persistent fever in the absence of infection or other underlying condition. The fever …

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Infectious disorders

Infectious diseases comprise those illnesses that are caused by microorganisms or their products. Clinical manifestations of infection occur only when sufficient tissue injury has been inflicted directly by microbial products (e.g., endotoxins and exotoxins), or indirectly by host responses (e.g., cytokines and hydrolytic enzymes released by polymorphonuclear leukocytes). Despite the extraordinary recent advances that have occurred in therapeutics for infectious diseases, a number of basic principles should be followed to prescribe antimicrobials and vaccines is an optimal manner. This chapter addresses the broader issues of treating infectious diseases and provides a number of practical clinical examples to demonstrate rational therapeutics. A rational therapeutic strategy in the management of proved or suspected …

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Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative …

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Spanish And French Translations Of Common Medication Words:

English Spanish French
Medications Medicamentos Médicaments
Tablets Comprimidos Comprimés
Capsules Cápsulas Gélules
Pharmacies in the United States
Top 10 Pharmacy chains in the U. S. ranked by the number of pharmacists:
1 Walgreens 2 CVS 3 Walmart 4 Rite Aid 5 Kroger
6 Target 7 Kaiser Permanente 8 Sears 9 Cardinal Health 10 Dominick's
Pharmacy-led chains in the United Kingdom
Alliance Boots The Co-operative Lloyds Pharmacy
Numark Rowlands Pharmacy Superdrug

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Dosage forms of Norfloxacin:

Name, Strength, Form, Route
Norfloxacin Tablet Oral

Therapeutic classes of Norfloxacin:

Anti-Bacterial Agents, Anti-Infectives, Enzyme Inhibitors, Nucleic Acid Synthesis Inhibitors, Quinolones

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Common brands (equivalents) of Norfloxacin, which people buy in pharmacies of the world:

(The World's Largest Pharmaceutical Companies: Abbott, Amgen, AstraZeneca, Baxter, Bayer, Bristol-Myers Squibb, Boots, CSL, Eli Lilly, Forest, GlaxoSmithKline, Hoffmann - La Roche, Johnson & Johnson, Merck & Co., Mylan, Novartis, Pfizer (with Wyeth), Sanofi - Aventis, Sandoz, Solvay, Takeda, Teva, UCB, Watson)
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