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Nalidixic Acid is authorised in the world under the following brand names: Cybis, Dixiben, Dixinal, Eucistin, Innoxalon, Jicsron, naladixic acid, Nalidic acid, Nalidixan, Nalidixate, Nalidixic acid USP27, Nalidixin, Nalidixinic acid, Nalitucsan, Nalix, Nalurin, Naxuril, NegGram, Negram, Nevigramon, Nogram, Sicmylon, Unaserus, Urisal, Uronidix, Wintomylon, Wintron.

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Nalidixic acid: Side Effects Nalidixic acid, the first quinolone, first introduced in 1962, is now only rarely used and has been supplanted by the fluoroquinolones. It is almost completely absorbed from the gastrointestinal tract and is rapidly eliminated by the kidneys, resulting in urinary concentrations 4-6 times higher than plasma concentrations. There are better drugs to treat urinary tract infections. General adverse effects The adverse effects of nalidixic acid tend to be toxic rather than allergic. Nervous system toxicity is predominant, including disturbances of sensory perception and benign intracranial hypertension, which is nearly exclusively found in babies and young children. Gastrointestinal toxicity and skin reactions also occur. Immunological and hypersensitivity reactions …

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative …

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Nalidixic Acid [NegGram 500mg] Drug Nomenclature Synonyms: Ácido nalidíxico; Acidum Nalidixicum; Kyselina nalidixová; NSC-82174; Nalidíxico, ácido; Nalidiksiinihappo; Nalidikso rūgštis; Nalidixinic Acid; Nalidixinsyra; Nalidixsav; Win-18320 BAN: Nalidixic Acid USAN: Nalidixic Acid INN: Nalidixic Acid [rINN (en)] INN: Ácido nalidíxico [rINN (es)] INN: Acide Nalidixique [rINN (fr)] INN: Acidum Nalidixicum [rINN (la)] INN: Налидиксовая Кислота [rINN (ru)] Chemical name: 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid Molecular formula: C12H12N2O3 =232.2 CAS: 389-08-2 ATC code: J01MB02 Read code: y02TS Pharmacopoeias. In Europe, Japan, and US.   European Pharmacopoeia, 6th ed., 2008 and Supplements 6.1 and 6.2 (Nalidixic Acid). An almost white or pale yellow, crystalline powder. Practically insoluble in water; slightly soluble in alcohol and in acetone; soluble in …

Dosage forms of Nalidixic Acid:
Nalidixic acid powder

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Anti-Infective Agents, Enzyme Inhibitors, Nucleic Acid Synthesis Inhibitors

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