Tags: Lorabid

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative […]

Loracarbef (Lorabid Capsules 200, 400 mg)

Loracarbef is a synthetic carbacephem antibiotic. Carbacephems are b-lactam antibiotics structurally and pharmacologically related to cephalosporins; however, carbacephems contain a methylene group instead of sulfur in the dihydrothiazine ring of the cephalosporin nucleus, resulting in a tetrahydropyridine ring. This structural modification does not affect microbiologic activity, but substantially improves stability in aqueous solution and in serum, plasma, and other body fluids. Loracarbef is the carba analog of cefaclor, a second generation cephalosporin. SumMon® (see Users Guide). For additional information on this drug until a more detailed monograph is developed and published, the manufacturer's labeling should be consulted. It is essential that the labeling be consulted for detailed information on the usual […]

Loracarbef

Drug Nomenclature Synonyms: KT-3777; LY-163892; Loracarbef; Loracarbefum; Lorakarbef; Lorakarbefi BAN: Loracarbef USAN: Loracarbef INN: Loracarbef [rINN (en)] INN: Loracarbef [rINN (es)] INN: Loracarbef [rINN (fr)] INN: Loracarbefum [rINN (la)] INN: Лоракарбеф [rINN (ru)] Chemical name: (6R,7S)-3-Chloro-8-oxo-7-d-phenylglycylamino-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate Molecular formula: C16H16ClN3O4,H2O =367.8 CAS: 76470-66-1 (anhydrous loracarbef); 121961-22-6 (loracarbef monohydrate) ATC code: J01DC08 Pharmacopoeias in US pH of a 10% suspension in water is between 3.0 and 5.5. Store in airtight containers. Adverse Effects and Precautions Adverse effects of loracarbef are generally similar to those of other beta lactams (see Benzy (penicillin, and Cefalotin). They include gastrointestinal disturbances, particularly diarrhoea, and hypersensitivity reactions such as skin rashes. Increases in liver enzymes and abnormalities […]

Sinusitis and Lorabid

Question from Gabriel I was diagnosed with sinusitis three weeks ago. I was put on Cefaclor for ten days. I just got sick again and the doctor said I still have sinusitis. I am now on pseudoeph/guaifen and LORABID. 1. Is it normal that I’ve been sick this long? 2. I am allergic to penicillin. Should I be taking this? Dear Gabriel: Sinusitis can be a very persistent infection, and therefore you may require multiple antibiotics. I usually will treat patients with a three week course of an antibiotic. It is usually good to add a decongestant and a mucolytic agent. With regards to your penicillin allergy, there is about a […]

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