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Leishmania

Leishmania & Trypanosoma The genera Leishmania and Trypanosoma are members of the family Trypanosomatidae. These protozoans cause diseases with widely varied clinical presentations as well as geographic distributions, including leishmaniasis, American trypanosomiasis (Chagas’ disease), and African trypanosomiasis (sleeping sickness). For example, the endemic zones for African and American trypanosomiasis do not overlap, the diseases are transmitted by different vectors, they involve distinct mechanisms of pathogenesis, and they follow different clinical courses. Nonetheless, the causative agents share important biological features. Each is a hemoflagellate with a kinetoplast containing its own chromosomal DNA with highly conserved and repeated elements, each forms a single flagellum at some point during its life cycle, and each …

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Dermatophytes

Essentials of Diagnosis Characteristic pattern of inflammation on glabrous skin surfaces. The active border of infection is scaly, red, and slightly elevated. Wet mount preparation with potassium hydroxide (10-20%). Skin scraping of the active border shows branching, translucent, rod-shaped filaments (hyphae) in keratinized material under low-power microscopy (10-40×). Hyphae are uniformly wide and regularly septated. Wood’s light examination (UV light at 365 nm) shows blue-green fluorescence for Microsporum canis and Microsporum audouinii. Trichophyton schoenleinii is pale green, and tinea versicolor shows white-yellow fluorescence. Culture should be performed with hair, nail, and skin specimens from particularly inflammatory lesions, to make a definitive mycologic diagnosis. General Considerations Dermatophytes are molds that infect keratinized …

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Fusarium, Penicillium, Paracoccidioides, & Agents of Chromomycosis

FUSARIUM INFECTION Essentials of Diagnosis Worldwide geographic distribution. Mold, septate hyphae 3-8 um in diameter. A rare infection in severely immunocompromised patients. Blood cultures often but not always positive. No serologic tests available. Cutaneous involvement is common feature. General Considerations A. Epidemiology. Fusarium spp. is an emerging fungal pathogen. Although long recognized as a cause of local infection involving nails, traumatized skin, or the cornea (eg, in contact lens wearers), deep or disseminated infection was not described until the mid 1970s. Despite its worldwide distribution and its frequent recovery from soil and vegetative material, infection is quite rare. Only ~ 100 cases involving invasive disease in immunosuppressed patients have been described …

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Chromomycosis

Essentials of Diagnosis Patients are usually immunocompetent. Found worldwide but usually in tropical or subtropical areas. Mold in culture; forms sclerotic body or muriform cell in tissue. Infection results from direct inoculation from contaminated soil or vegetative substances. Chronic indolent cutaneous verrucous lesions, most often on the feet. General Considerations Chromomycosis, also known as chromoblastomycosis, is a chronic subcutaneous infection caused by several different fungi. Although rarely seen in the United States, it is common worldwide. A. Epidemiology. Chromomycosis occurs worldwide but is most frequently encountered in tropical and subtropical regions. The most common occurrence is in barefoot individuals, particularly among agricultural workers. The organisms causing chromomycosis are found commonly in …

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Paracoccidioidomycosis

Essentials of Diagnosis Patients usually immunocompetent. Patients in endemic areas with chronic pulmonary and mucotaneous lesions involving the mouth, nose, larynx, and face; regional or diffuse lymphadenopathy. Found in Latin America, from Mexico to Argentina. Dimorphic fungus: yeast form in tissue specimens and at 37 °C; mold form when grown at room temperature in the laboratory. Thick-walled yeast, 4-40 um, with multiple buds when seen in tissue specimens. Complement fixation or immunodiffusion. General Considerations Paracoccidioidomycosis is caused by Paracoccidioides brasiliensis. Also known as South American blastomycosis, it is the most prevalent systemic mycosis found in Central and South America and is the most common endemic mycosis in this area. A. Epidemiology. …

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Pseudallescheria Boydii Infection

Essentials of Diagnosis Filamentous fungus that is morphologically similar to Aspergillus spp. Most serious infections occur in immunosuppressed patients. Recovery from culture must be distinguished from colonization or contamination. General Considerations P boydii is a mold that is capable of causing infection in immunosuppressed patients and less frequently in immunocompetent patients. Overall, infection with P boydii is rare. A. Epidemiology. Although a relatively common environmental mold, P boydii is a rare cause of human disease. It can be easily recovered from soil, water, and manure. Both community and nosocomial acquisition have been documented. In most instances, its recovery from culture specimens will reflect colonization or contamination; however, it is capable of …

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Candida Vulvovaginitis

Clinical Findings A. Signs and Symptoms. Risk factors for Candida infection of the vagina include pregnancy, oral contraceptive use, diabetes mellitus, HIV infection, and antimicrobial therapy, although the majority of infections occur in the absence of these risks. Typical complaints are vulvar pruritus and vaginal discharge (Box 1), although a wide range of symptoms exists. Pruritus, the most common complaint, is often intense, and the discharge, classically described as cottage cheese-like, may range from a thin, white, scant discharge to homogeneously thick. Odor, if present, is mild. Other symptoms may include vulvar burning, external dysuria, vaginal irritation and soreness, and dyspareunia. Symptoms may peak the week prior to menses and wane …

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Candida Dermatitis (Candida rash)

Clinical Findings A. Signs and Symptoms. Skin infections with Candida are common and may manifest in a variety of forms. Intertrigo occurs in warm, moist areas of skin, such as under the breast, in the groin, and in the axilla. Initially pustular or vesicular, lesions eventually become confluent to form an erythematous, macerated area of skin with a scalloped border and satellite lesions (Box 1). Erosio interdigitalis blastomycetica is similar to intertrigo but involves the areas between the fingers and toes. Paronychia is infection of the nail bed, seen more commonly in diabetics and people who frequently immerse their hands in water. Candida spp. may cause onychomycosis, particularly in HIV-infected patients. …

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Blastomyces Dermatitidis (Blastomycosis)

Essentials of Diagnosis Round thick-walled yeast with broad-based budding. Dimorphic: mycelial in nature, yeast in tissue. Associated with activities in proximity to waterways. Associated with exposure to dust, eg excavation. Endemic in states surrounding the Mississippi and Ohio Rivers. Pyogranulomas on histopathological examination. Acute or chronic infection of lung, skin, bone, or genitourinary tract. Recovery of microorganism from culture of tissue. General Considerations A. Epidemiology. Blastomyces dermatitidis is an endemic fungus that causes acute and chronic infections in humans and other animals. It is found primarily in the south central, southeastern, and midwestern United States, especially in the states surrounding the Mississippi and Ohio Rivers. Outside the United States, cases have …

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Histoplasma Capsulatum

Essentials of Diagnosis Thin-walled oval yeast measuring 2-4 mm in diameter. Dimorphic: mycelial in nature, yeast in tissue. Endemic within Ohio and Mississippi River Valleys. Associated with activities that disturb dust or soil enriched with bird, chicken, and bat excrement. Complement fixation antibody titer 1:32 or greater. Simultaneous appearance of anti-H and anti-M antibodies. Infection most often is asymptomatic or may cause chronic pulmonary infection; less commonly, disseminated infection involving the adrenals, ulcerative gastroenteritis lesions, or central nervous system. Recovery of organism from culture of tissue, blood, sputum, or other source. General Considerations A. Epidemiology. Histoplasma capsulatum, the etiologic agent of histoplasmosis, is an endemic, dimorphic fungus that causes a wide …

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Spanish And French Translations Of Common Medication Words:

English Spanish French
Medications Medicamentos Médicaments
Tablets Comprimidos Comprimés
Capsules Cápsulas Gélules
Pharmacies in the United States
Top 10 Pharmacy chains in the U. S. ranked by the number of pharmacists:
1 Walgreens 2 CVS 3 Walmart 4 Rite Aid 5 Kroger
6 Target 7 Kaiser Permanente 8 Sears 9 Cardinal Health 10 Dominick's
Pharmacy-led chains in the United Kingdom
Alliance Boots The Co-operative Lloyds Pharmacy
Numark Rowlands Pharmacy Superdrug

Synonyms of Ketoconazole *:

2%, Ketocanazole, Ketoconazol, Ketoconazol [INN-Spanish], ketoconazole, Ketoconazole [Usan:Ban:Inn:Jan], Ketoconazolum [INN-Latin]

* Official titles and synonyms used in the British, European, and US Pharmacopoeias. INNs in the other main official languages (French, Latin, and Spanish) have also been included in the list of synonyms where these differ from the English INN.

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Dosage forms of Ketoconazole:

Name, Strength, Form, Route
Ketoconazole Cream Topical
Ketoconazole Shampoo Topical
Ketoconazole Tablet Oral

Therapeutic classes of Ketoconazole:

Antifungal Agents, Antifungals

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Common brands (equivalents) of Ketoconazole, which people buy in pharmacies of the world:

(The World's Largest Pharmaceutical Companies: Abbott, Amgen, AstraZeneca, Baxter, Bayer, Bristol-Myers Squibb, Boots, CSL, Eli Lilly, Forest, GlaxoSmithKline, Hoffmann - La Roche, Johnson & Johnson, Merck & Co., Mylan, Novartis, Pfizer (with Wyeth), Sanofi - Aventis, Sandoz, Solvay, Takeda, Teva, UCB, Watson)
(Australia, Canada, India, Mexico, New Zealand, USA, Europe [Belgium, France, Germany, Holland, Ireland, Spain, Switzerland, Great Britain (UK), Italy], and etc)
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