Tags: Gantrisin

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative […]

Sulfisoxazole, Sulfisoxazole Acetyl

Sulfisoxazole is a short-acting sulfonamide. Uses Sulfisoxazole and its derivatives share the actions and uses of the sulfonamides. The relative solubility of the drug in alkaline and slightly acidic urine makes the drug particularly useful for the treatment of urinary tract infections. A combination product containing sulfisoxazole acetyl and erythromycin ethylsuccinate is commercially available for the treatment of acute otitis media caused by susceptible strains of Haemophilus influenzae in children and is usually active against ampicillin-resistant strains of the organism. For information on dosage and administration of the combination product. Although sulfisoxazole-containing creams previously have been used intravaginally in the treatment of bacterial vaginosis (formerly called Haemophilus vaginitis, Gardnerella vaginitis, nonspecific […]

Treatment for melioidosis

Question: What is the current treatment for melioidosis? Answer: Melioidosis is an infectious disease caused by a bacterium called Pseudomonas pseudomallei. The disease has several forms depending on the location of the infection, each varying in severity. Melioidosis is most frequently reported in Southeast Asia. The bacterium that causes the disease is found in the soil, rice paddies, and stagnant waters of the area. Humans contract the disease when the contaminated soil contacts skin abrasions (tears). Melioidosis most commonly involves the lungs where the infection can form a cavity of pus (abscess). It can spread from the skin through the blood to affect the heart, brain, liver, kidneys, joints, and eyes. […]