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Giardia: Clinical Syndromes

After ingestion of G lamblia cysts, 5-15% of patients will have asymptomatic cyst passage, and 25-50% of patients will have diarrhea. From 35% to 70% of these patients will have no evidence of infection. The three manifestations of infection include asymptomatic cyst passage, self-limited diarrhea, and chronic diarrhea with associated malabsorption and weight loss. Factors related to each of these manifestations are unknown but are believed to be related to specific host factors, parasite load, and virulence variation among G lamblia isolates. ACUTE GIARDIASIS Clinical Findings Signs and Symptoms After ingestion of cysts, an incubation period of 3-20 days exists before symptom onset. At the time of presentation, patients have generally […]

Vibrio & Campylobacter

VIBRIO CHOLERAE INFECTIONS Essentials of Diagnosis History of exposure, particularly travel to endemic or epidemic locales. Acute onset of voluminous, watery diarrhea, with low-grade fever and mild abdominal pain, which are disproportionate to the amount of diarrhea. During outbreaks, the presence of straight-to-curved gram-negative bacilli, with a single polar flagellum, in the stool of infected patients. In wet preparations, these organisms demonstrate a characteristic darting or "shooting star" motility. The identification may be confirmed by motility inhibition with specific antisera. Cultures of V cholerae from stool with differential media, such as thiosulfate-citrate-bile salts-sucrose (TCBS) medium. Bacterial growth in nutrient broth, without 1% NaCl supplementation. This characteristic is useful for separating V […]

Vibrio Cholerae Infections: Clinical Syndromes

Cholera is a fulminant diarrheal disease caused by V cholerae (Box 1). Patients with cholera develop frequent, watery stools, which may reach volumes =1 L/h. If these patients are untreated, they will develop rapid dehydration and electrolyte abnormalities, which may result in death within hours from the onset of disease. Therefore cholera is a medical emergency. V cholerae is noninvasive and produces diarrhea by the elaboration of a potent enterotoxin. This enterotoxin consists of two subunits that have been well characterized. The circular, pentameric B-subunit binds monosialosyl ganglioside residues on the surface of the intestinal epithelial cell and introduces the enzymatic A-subunit into the cytoplasm. The A-subunit functions as an adenosine […]


Description of Medical Condition An acute infectious disease caused by Vibrio cholerae (El Tor type is responsible for current epidemic, the other type, classic, is found only in Bangladesh). (New serotype now in Bangladesh, India (0139). Important because of lack of efficacy of standard vaccine.) Characteristics include severe diarrhea with extreme fluid and electrolyte depletion, and vomiting, muscle cramps and prostration. Usual course: acute; chronic; relapsing. Clinical course is 3-5 days, and in the early stages a severely affected patient can lose one liter of fluid per hour Endemic areas: India; Southeast Asia; Africa; Middle East; Southern Europe; Oceania; South and Central America System(s) affected: Gastrointestinal Genetics: N/A Incidence/Prevalence in USA: […]

Bacterial Infections

The bacterial species most commonly associated with gastrointestinal infection and infectious diarrhea in the United States are Shigella spp., Salmonella spp., Campylobacter spp., Yersinia spp., Escherichia spp., Clostridium spp., and Staphylococcus spp. Antibiotics are not essential in the treatment of most mild diarrheas, and empirical therapy for acute gastrointestinal infections may result in unnecessary antibiotic courses. Enterotoxigenic (cholera-like) Diarrhea Cholera (Vibrio cholerae) Vibrio cholerae is the organisms that most often causes human epidemics and pandemics. Four mechanisms for transmission have been proposed: animal reservoirs, chronic carriers, asymptomatic or mild disease victims, or water reservoirs. TABLE. Clinical Assessment of Degree of Dehydration in Children Based on Percentage of Body Weight Lossa Variable […]

Toxicity of Antimicrobial Therapy

Mechanisms of toxicity The mechanisms associated with common adverse reactions to antimicrobials include dose-related toxicity that occurs in a certain fraction of patients when a critical plasma concentration or total dose is exceeded, and toxicity that is unpredictable and mediated through allergic or idiosyncratic mechanisms. For example, certain classes of drugs such as the aminoglycosides are associated with dose-related toxicity. In contrast, the major toxicity of the penicillins and cephalosporins is due to allergic reactions. These differences are explained in part by the relative ability of specific drugs to inhibit enzymatic pathways in the host versus their stimulation of specific immune response. Not included in these lists is mention of the […]

Tetracyclines General Statement: Uses

Tetracyclines are used principally in the treatment of infections caused by susceptible Rickettsia, Chlamydia, Mycoplasma, and a variety of uncommon gram-negative and gram-positive bacteria. Because of the development of resistance, tetracyclines are rarely used for the treatment of infections caused by common gram-negative or gram-positive bacteria unless other appropriate anti-infectives are contraindicated or are ineffective and in vitro susceptibility tests indicate that the causative organisms are susceptible to the drugs. Generally, given a susceptible organism, the currently available tetracyclines are all equally effective when administered in appropriate dosages. Because minocycline and, to a lesser extent, doxycycline penetrate most body tissues and fluids better than do other currently available tetracyclines, some clinicians […]

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Co-trimoxazole: Uses Urinary Tract Infections Co-trimoxazole is used for the treatment of urinary tract infections (UTIs) caused by susceptible strains of E. coli, Proteus (indole-positive or -negative), Klebsiella, Morganella morganii, or Enterobacter. Co-trimoxazole, given in single doses, as 3-day therapy, or for 7-10 days, is effective in the treatment of acute uncomplicated UTIs. Some clinicians consider a 3-day regimen of co-trimoxazole the treatment of choice for the empiric treatment of acute uncomplicated UTIs. Co-trimoxazole also is used for the treatment of acute complicated UTIs (e.g., UTIs associated with abnormalities of the urinary tract or neurogenic bladder), but other anti-infectives are preferred by most clinicians. F or the treatment of acute pyelonephritis, […]

Buy Noroxin (Norfloxacin) Without Prescription 400mg

Norfloxacin: Uses Norfloxacin is used in adults for the treatment of complicated and uncomplicated urinary tract infections and prostatitis caused by susceptible organisms and for the treatment of uncomplicated gonorrhea. Norfloxacin also has been used in adults for the treatment of various GI infections caused by susceptible organisms. Because only low serum concentrations of norfloxacin are attained after oral administration of usual dosages, use of the drug is generally limited to genitourinary or GI tract infections. Prior to initiation of norfloxacin therapy, appropriate specimens should be obtained for identification of the causative organism and in vitro susceptibility tests. Norfloxacin may be initiated, however, before obtaining the results of these tests. If […]

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Ciprofloxacin Hydrochloride: Uses Ciprofloxacin is used orally or IV in adults for the treatment of urinary tract infections, chronic bacterial prostatitis, acute sinusitis, lower respiratory tract infections, skin and skin structure infections, or bone and joint infections caused by susceptible gram-negative and gram-positive aerobic bacteria. Ciprofloxacin is used orally or IV for inhalational anthrax (postexposure) following suspected or confirmed exposure to aerosolized Bacillus anthracis spores and also is used for prophylaxis following ingestion of B. anthracis spores and for the treatment of inhalational anthrax, cutaneous anthrax, or GI and oropharyngeal anthrax. Ciprofloxacin also is used orally for the treatment of acute sinusitis, uncomplicated cervical and urethral gonorrhea, typhoid fever, and GI […]

Dosage forms of Furazolidone:
Furazolidone powder

Synonyms of Furazolidone:

Nitrofurazolidone, Nitrofurazolidonum, USAF EA-1

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Therapeutic classes of Furazolidone:

Anti-Infective Agents, Local, Anti-Infective Agents, Urinary, Antitrichomonal Agents, Monoamine Oxidase Inhibitors


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