Tags: Fortaz

Specific Anti-Infective Agents

Antibiotics Before prescribing a specific antibiotic, clinicians should be able to answer these questions: How does the antibiotic kill or inhibit bacterial growth? What are the antibiotic's toxicities and how should they be monitored? How is the drug metabolized, and what are the dosing recommendations? Does the dosing schedule need to be modified in patients with renal dysfunction? What are the indications for using each specific antibiotic? How broad is the antibiotic's antimicrobial spectrum? How much does the antibiotic cost? Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in each class can be subtle, often […]

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative […]

Ceftazidime

Ceftazidime is a semisynthetic, third generation cephalosporin antibiotic. Uses Ceftazidime is used for the treatment of bone and joint infections, intra-abdominal and gynecologic infections, meningitis and other CNS infections, lower respiratory tract infections, skin and skin structure infections, and complicated or uncomplicated urinary tract infections caused by susceptible bacteria. The drug also is used for empiric anti-infective agent therapy in febrile neutropenic patients and has been used for perioperative prophylaxis. Ceftazidime therapy may be started pending results of susceptibility tests, but should be discontinued if the organism is found to be resistant to the drug. When the causative organism is unknown, concomitant therapy with another anti-infective agent may be indicated pending […]

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