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Leishmania

Leishmania & Trypanosoma The genera Leishmania and Trypanosoma are members of the family Trypanosomatidae. These protozoans cause diseases with widely varied clinical presentations as well as geographic distributions, including leishmaniasis, American trypanosomiasis (Chagas’ disease), and African trypanosomiasis (sleeping sickness). For example, the endemic zones for African and American trypanosomiasis do not overlap, the diseases are transmitted by different vectors, they involve distinct mechanisms of pathogenesis, and they follow different clinical courses. Nonetheless, the causative agents share important biological features. Each is a hemoflagellate with a kinetoplast containing its own chromosomal DNA with highly conserved and repeated elements, each forms a single flagellum at some point during its life cycle, and each …

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Cryptosporidium, Cyclospora, & Isospora Species & Microsporidia

Within the last decade, the AIDS epidemic has heightened awareness of several gastrointestinal spore-forming protozoan pathogens. The genera Cryptosporidium, Isospora, and Cyclospora are members of the subclass Coccidia and phylum Apicomplexa; the microsporidia are a group of organisms belonging to the phylum Microspora. The spectrum of disease caused by these protozoans goes beyond gastrointestinal manifestations, and the significance of these protozoan infections is becoming increasingly appreciated in both immunocompromised and immunocompetent hosts. CRYPTOSPORIDIUM Essentials of Diagnosis • Key signs and symptoms include dehydration with watery diarrhea of variable quantity. • Waterborne transmission is the most common mode of oocyst transmission. • Patients at risk for person-to-person transmission include household contacts, sexual …

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Fusarium, Penicillium, Paracoccidioides, & Agents of Chromomycosis

FUSARIUM INFECTION Essentials of Diagnosis Worldwide geographic distribution. Mold, septate hyphae 3-8 um in diameter. A rare infection in severely immunocompromised patients. Blood cultures often but not always positive. No serologic tests available. Cutaneous involvement is common feature. General Considerations A. Epidemiology. Fusarium spp. is an emerging fungal pathogen. Although long recognized as a cause of local infection involving nails, traumatized skin, or the cornea (eg, in contact lens wearers), deep or disseminated infection was not described until the mid 1970s. Despite its worldwide distribution and its frequent recovery from soil and vegetative material, infection is quite rare. Only ~ 100 cases involving invasive disease in immunosuppressed patients have been described …

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Chromomycosis

Essentials of Diagnosis Patients are usually immunocompetent. Found worldwide but usually in tropical or subtropical areas. Mold in culture; forms sclerotic body or muriform cell in tissue. Infection results from direct inoculation from contaminated soil or vegetative substances. Chronic indolent cutaneous verrucous lesions, most often on the feet. General Considerations Chromomycosis, also known as chromoblastomycosis, is a chronic subcutaneous infection caused by several different fungi. Although rarely seen in the United States, it is common worldwide. A. Epidemiology. Chromomycosis occurs worldwide but is most frequently encountered in tropical and subtropical regions. The most common occurrence is in barefoot individuals, particularly among agricultural workers. The organisms causing chromomycosis are found commonly in …

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Cryptococcus Neoformans

Essentials of Diagnosis Routine laboratory tests often normal. One-third of patients are afebrile. Definitive diagnosis made by fungal culture maintained at 37°C for 6 weeks. Cryptococcal antigen 95% sensitive in CNS infection in centrifuged CSF. India ink examination positive in only 50% of meningoencephalitis cases. CSF lymphocytes often low in CNS infection, especially in AIDS patients. Cryptococcal antigen most sensitive detection method in serum. Chest radiograph variable — multiple areas of infiltration in lower lobes most common in pulmonary disease. Molecular detection by PCR might soon become laboratory standard. General Considerations A. Epidemiology and Ecology. Cryptococcus neoformans exists as two distinct varieties known as variety neoformans and variety gattii (Table 1). …

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Candida Species

Essentials of Diagnosis Characteristic appearance of yeast and hyphae on KOH preparations. Formation of germ tubes in serum is presumptive diagnosis for Candida albicans. Cultures must be interpreted with caution because positive culture may represent colonization rather than infection. Serology not useful. General Considerations A. Epidemiology. Candida organisms are commensal with humans and, in the absence of alterations in host defense mechanisms, usually do not cause disease. Candida exists as normal flora within the oral cavity, throughout the gastrointestinal (GI) tract, in expectorated sputum, in the vagina, and in the bladder of patients with indwelling catheters. There are >150 species within the genus Candida, although the majority are not known to …

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Candidemia & Disseminated Candidiasis

Candidemia may present in a variety of fashions, ranging from asymptomatic to fulminant sepsis. The candidemic patient generally has risk factors for infection, such as malignancy, chemotherapy-induced neutropenia, organ transplantation, GI surgery, burns, indwelling catheters, or exposure to broad-spectrum antibiotics. Disseminated candidiasis must be assumed to be present in those with positive blood cultures, although negative cultures do not preclude the possibility of disseminated disease. Dissemination usually manifests with many microabscesses involving multiple organs, especially the liver, spleen, and eye, but almost any organ may be involved (Box 2). Diagnosis Candidemia is diagnosed by recovering Candida species in blood culture. Candidemia may be isolated or may occur in the setting of …

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Candiduria, Candida Cystitis & Urinary Tract Candidiasis

The presence of Candida spp. in the urine is common and does not necessarily represent infection. Candiduria is commonly associated with antibiotic use, indwelling urinary catheters, and diabetes mellitus and frequently resolves if predisposing factors can be corrected. Patients are generally asymptomatic, although some will have symptoms similar to bacterial cystitis, with dysuria, frequency, and urgency (Box 2). Urinalysis shows fungal elements and may reveal pyuria. At cystoscopy, the mucosa of the bladder typically has an inflamed appearance with adherent white plaques that may be removed with the scope. Candida spp. may also cause urethritis, typically in male sexual partners of women with vaginal Candida infection, as well as higher urinary …

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Candida Vulvovaginitis

Clinical Findings A. Signs and Symptoms. Risk factors for Candida infection of the vagina include pregnancy, oral contraceptive use, diabetes mellitus, HIV infection, and antimicrobial therapy, although the majority of infections occur in the absence of these risks. Typical complaints are vulvar pruritus and vaginal discharge (Box 1), although a wide range of symptoms exists. Pruritus, the most common complaint, is often intense, and the discharge, classically described as cottage cheese-like, may range from a thin, white, scant discharge to homogeneously thick. Odor, if present, is mild. Other symptoms may include vulvar burning, external dysuria, vaginal irritation and soreness, and dyspareunia. Symptoms may peak the week prior to menses and wane …

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Esophageal Candidiasis

Clinical Findings A. Signs and Symptoms. Candida infection of the esophagus can present with a range of clinical findings (Box 1). Between 20 and 50% of patients may be asymptomatic. Others will note dysphagia, odynophagia, epigastric pain, nausea and vomiting, or hematemesis. Fever may be present. Frequently, patients will have concurrent symptoms of oral thrush. Physical exam of patients with esophagitis yields few clues to its diagnosis. Oral thrush is seen in the majority. B. Imaging. Barium studies and endoscopy are both useful for diagnosis of Candida esophagitis. The findings found with these methods are described in the diagnosis section. C. Differential Diagnosis. Candida esophagitis may be confused with other causes …

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Spanish And French Translations Of Common Medication Words:

English Spanish French
Medications Medicamentos Médicaments
Tablets Comprimidos Comprimés
Capsules Cápsulas Gélules
Pharmacies in the United States
Top 10 Pharmacy chains in the U. S. ranked by the number of pharmacists:
1 Walgreens 2 CVS 3 Walmart 4 Rite Aid 5 Kroger
6 Target 7 Kaiser Permanente 8 Sears 9 Cardinal Health 10 Dominick's
Pharmacy-led chains in the United Kingdom
Alliance Boots The Co-operative Lloyds Pharmacy
Numark Rowlands Pharmacy Superdrug

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Dosage forms of Fluconazole:

Name, Strength, Form, Route
Fluconazole Capsule Oral
Fluconazole Liquid Intravenous
Fluconazole Powder, for solution Oral
Fluconazole Solution Intravenous
Fluconazole Tablet Oral

Therapeutic classes of Fluconazole:

Antifungal Agents, Antifungals

Do I need a Prescription to buy Fluconazole in Online Pharmasy?
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Common brands (equivalents) of Fluconazole, which people buy in pharmacies of the world:

(The World's Largest Pharmaceutical Companies: Abbott, Amgen, AstraZeneca, Baxter, Bayer, Bristol-Myers Squibb, Boots, CSL, Eli Lilly, Forest, GlaxoSmithKline, Hoffmann - La Roche, Johnson & Johnson, Merck & Co., Mylan, Novartis, Pfizer (with Wyeth), Sanofi - Aventis, Sandoz, Solvay, Takeda, Teva, UCB, Watson)
(Australia, Canada, India, Mexico, New Zealand, USA, Europe [Belgium, France, Germany, Holland, Ireland, Spain, Switzerland, Great Britain (UK), Italy], and etc)
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