Tags: Dirithromycin

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative …

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Toxicity of Antimicrobial Therapy

Mechanisms of toxicity The mechanisms associated with common adverse reactions to antimicrobials include dose-related toxicity that occurs in a certain fraction of patients when a critical plasma concentration or total dose is exceeded, and toxicity that is unpredictable and mediated through allergic or idiosyncratic mechanisms. For example, certain classes of drugs such as the aminoglycosides are associated with dose-related toxicity. In contrast, the major toxicity of the penicillins and cephalosporins is due to allergic reactions. These differences are explained in part by the relative ability of specific drugs to inhibit enzymatic pathways in the host versus their stimulation of specific immune response. Not included in these lists is mention of the …

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Dirithromycin

C42H78N2O14 • Dirithromycin is a semisynthetic macrolide antibiotic. Uses Dirithromycin is used for the treatment of mild to moderate upper and lower respiratory tract and skin and skin structure infections caused by susceptible organisms. Dirithromycin should not be used in patients with known, suspected, or potential bacteremia since serum concentrations achievable with oral therapy are inadequate to provide antibacterial coverage in such infections. As with other anti-infective agents, use of dirithromycin may result in overgrowth of nonsusceptible bacteria or fungi. If superinfection occurs, appropriate therapy should be instituted. While Clostridium difficile-associated diarrhea and colitis (also known as antibiotic-associated pseudomembranous colitis) caused by overgrowth of toxin-producing clostridia has been reported rarely with …

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Purchase Clarithromycin (Biaxin) No Prescription 250/500mg

Clarithromycin • Clarithromycin is a semisynthetic macrolide antibiotic with a broader spectrum than that of erythromycins. Uses Clarithromycin is used orally for the treatment of pharyngitis and tonsillitis, mild to moderate respiratory tract infections (acute bacterial exacerbation of chronic bronchitis, acute maxillary sinusitis, community-acquired pneumonia), uncomplicated skin and skin structure infections, and acute otitis media caused by susceptible organisms. Clarithromycin also is used orally in the treatment of disseminated infections caused by Mycobacterium avium complex (MAC) in patients with advanced human immunodeficiency virus (HIV) infection and for prevention of disseminated MAC infection (both primary and secondary prophylaxis) in HIV-infected individuals. Oral clarithromycin is used in combination with amoxicillin and lansoprazole or …

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Buy Azithromycin (Zithromax) Without Prescription 250/500mg

Azithromycin • Azithromycin is a semisynthetic azalide antibiotic, a subclass of macrolide antibiotics, with a broader spectrum than that of erythromycins or clarithromycin. Uses Azithromycin is used orally in adults for the treatment of mild to moderate upper and lower respiratory tract infections and uncomplicated skin and skin structure infections caused by susceptible organisms. Oral azithromycin also is used for the treatment of urethritis or cervicitis caused by Chlamydia trachomatis or Neisseria gonorrhoeae, and for the treatment of chancroid caused by Haemophilus ducreyi. Azithromycin is used orally for the treatment of disseminated infections caused by Mycobacterium avium complex (MAC) in patients with human immunodeficiency virus (HIV) infection and for prevention of …

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Order Ilosone (Erythromycin) No Prescription 250\500mg

Erythromycin • Erythromycins are macrolide antibiotics that are active principally against gram-positive cocci and bacilli and to a lesser extent gram-negative cocci and bacilli; the drugs also exhibit activity against chlamydia, mycoplasma, ureaplasma, spirochetes, and mycobacteria. Uses Prior to initiation of erythromycin therapy, appropriate specimens should be obtained for identification of the causative organism and in vitro susceptibility tests. Use of erythromycin does not preclude the necessity for surgical procedures (such as incision and drainage) as needed. There does not appear to be a difference in clinical efficacy among the erythromycin derivatives when each is administered in appropriate doses. However, some clinicians believe that the risk of hepatotoxicity from the estolate …

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Purchase Erythromycin (Ilosone) Without Prescription 250/500mg

Macrolides: Erythromycin, Clarithromycin Overview Macrolides are a class of drugs that inhibit bacterial protein synthesis. They demonstrate excellent activity against atypical organisms (Mycoplasma, Chlamydia, and Legionella species), but have variable activity against typical pathogens (S. pneumoniae and H. influenzae). Macrolides are indicated for use in mild-to-moderate community-acquired pneumonia and are typically used as first- and second-line agents for this indication. Likewise, they are used in combination with penicillins or cephalosporins for severe community-acquired pneumonia to provide atypical pathogen coverage. Although resistance levels to the macrolides may differ among the various agents in this class, cross-resistance is assumed for gram-positive organisms. The macrolides are available in oral and parenteral formulations. Compared with …

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Macrolides

Overview.Macrolides inhibit bacterial protein synthesis. They demonstrate excellent activity against atypical organisms (Mycoplasma, Chlamydia, and Legionella species), but their activity against typical pathogens (H. influenzae and S. pneumoniae) is variable. Macrolides are indicated for use in acute exacerbations of chronic bronchitis and are typically used as first- and second-line agents for this indication. They are available in oral and parenteral formulations. The advanced-generation macrolides have serum half-lives that are much longer than earlier-generation agents, allowing for once-daily dosing. In addition, the newer macrolides demonstrate better activity against S. pneumoniae and excellent distribution into respiratory tissues. Side effects, particularly of the early macrolides, are associated primarily with the GI tract (e.g., abdominal …

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