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Candida Species

Essentials of Diagnosis Characteristic appearance of yeast and hyphae on KOH preparations. Formation of germ tubes in serum is presumptive diagnosis for Candida albicans. Cultures must be interpreted with caution because positive culture may represent colonization rather than infection. Serology not useful. General Considerations A. Epidemiology. Candida organisms are commensal with humans and, in the absence of alterations in host defense mechanisms, usually do not cause disease. Candida exists as normal flora within the oral cavity, throughout the gastrointestinal (GI) tract, in expectorated sputum, in the vagina, and in the bladder of patients with indwelling catheters. There are >150 species within the genus Candida, although the majority are not known to …

Candida Vulvovaginitis

Clinical Findings A. Signs and Symptoms. Risk factors for Candida infection of the vagina include pregnancy, oral contraceptive use, diabetes mellitus, HIV infection, and antimicrobial therapy, although the majority of infections occur in the absence of these risks. Typical complaints are vulvar pruritus and vaginal discharge (Box 1), although a wide range of symptoms exists. Pruritus, the most common complaint, is often intense, and the discharge, classically described as cottage cheese-like, may range from a thin, white, scant discharge to homogeneously thick. Odor, if present, is mild. Other symptoms may include vulvar burning, external dysuria, vaginal irritation and soreness, and dyspareunia. Symptoms may peak the week prior to menses and wane …

Candida Dermatitis (Candida rash)

Clinical Findings A. Signs and Symptoms. Skin infections with Candida are common and may manifest in a variety of forms. Intertrigo occurs in warm, moist areas of skin, such as under the breast, in the groin, and in the axilla. Initially pustular or vesicular, lesions eventually become confluent to form an erythematous, macerated area of skin with a scalloped border and satellite lesions (Box 1). Erosio interdigitalis blastomycetica is similar to intertrigo but involves the areas between the fingers and toes. Paronychia is infection of the nail bed, seen more commonly in diabetics and people who frequently immerse their hands in water. Candida spp. may cause onychomycosis, particularly in HIV-infected patients. …

Management of Tinea Manuum (Terbinafine, Itraconazole)

Definition of Tinea Manuum The term tinea manuum is used to refer to dermatophyte infections of one or both hands. Geographical distribution of Tinea Manuum The condition is worldwide in distribution. Causal organisms The anthropophilic dermatophytes E. floccosum, T. mentagrophytes var. interdigitate and T. rubrutn are the most common causes of tinea manuum. Less commonly, the condition is caused by zoophilic dermatophytes, such as M. canis and T. verrucosum, or geophilic dermatophytes, such as M. gypseum. Hand infection may be acquired as a result of contact with another person, with an animal, or with soil, either through direct contact, or via a contaminated object such as a towel or gardening tool. Autoinoculation from …

Management of Tinea Pedis (Terbinafine, Itraconazole)

Definition of Tinea Pedis The term tinea pedis is used to refer to dermatophyte infections of the feet. These infections often involve the interdigital spaces, but chronic diffuse desquamation can affect the entire sole. Geographical distribution of Tinea Pedis The condition is worldwide in distribution. Causal organisms The anthropophilic dermatophytes E. floccosum, T. mentagrophytes var. interdigitale and T. rubrutn are the commonest causes of tinea pedis in the UK and North America. T. rubrutn is the principal cause of chronic tinea pedis. T. mentagrophytes usually causes more inflammatory lesions. Tinea pedis is a very widespread condition that appears to be increasing in prevalence. It often begins in late childhood or young adult life …

Management of Tinea Corporis (Griseofulvin, Terbinafine, Itraconazole)

Definition of Tinea Corporis The term tinea corporis is used to refer to dermatophyte infections of the trunk, legs and arms, but excluding the groin, hands and feet. Geographical distribution of Tinea Corporis The condition is worldwide in distribution, but is most prevalent in tropical and subtropical regions. Causal organisms Tinea corporis is caused by E. floccosum and many species of Trichophyton and Microsporum. Infection with anthropophilic species, such as E. floccosum or T. rubrum often follows autoinoculation from another infected body site, such as the feet. Tinea corporis caused by T. tonsurans is sometimes seen in children with tinea capitis and their close contacts. Tinea corporis commonly occurs following contact …

Management of Tinea Capitis (Terbinafine, Itraconazole)

Definition of Tinea Capitis The term tinea capitis is used to refer to dermatophyte infections of the scalp and hair. Geographical distribution of Tinea Capitis The condition is worldwide in distribution, but is most prevalent in Africa, Asia and southern and eastern Europe, where it is the most common form of dermatophytosis. Improved standards of hygiene and prompt eradication of sporadic infection have led to a marked decline in the incidence of tinea capitis in North America and western Europe. Favus used to be worldwide in distribution, but is now confined to North Africa, the Middle East and parts of southern and eastern Europe. Causal organisms Tinea capitis is caused by a number …

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Fluconazole [US: Diflucan 50mg, 100mg, 150mg, 200mg] (British Approved Name, US Adopted Name, rINN) Drug Nomenclature Synonyms: Fluconazol; Fluconazolum; Flukonatsoli; Flukonazol; UK-49858 BAN: Fluconazole USAN: Fluconazole INN: Fluconazole [rINN (en)] INN: Fluconazol [rINN (es)] INN: Fluconazole [rINN (fr)] INN: Fluconazolum [rINN (la)] INN: Флуконазол [rINN (ru)] Chemical name: 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol Molecular formula: C13H12F2N6O =306.3 CAS: 86386-73-4 ATC code: D01AC15; J02AC01 Read code: y02Ug Pharmacopoeias. In China, Europe, and US. European Pharmacopoeia, 6th ed. (Fluconazole). A white or almost white, hygroscopic, crystalline powder. It exhibits polymorphism. Slightly soluble in water freely soluble in methyl alcohol soluble in acetone. Store in airtight containers. The United States Pharmacopeia 31, 2008, and Supplements 1 and 2 …


Description of Medical Condition An acute, spreading infection of the dermis and subcutaneous tissue. Several entities are recognized: • Cellulitis of the extremities — characterized by an expanding, red, swollen, tender or painful plaque with an indefinite border that may cover a wide area • Recurrent cellulitis of the leg after saphenous venectomy — patients have an acute onset of swelling, erythema of the legs arising months to years after coronary artery bypass. (Surgery using lower extremity veins for bypass grafts.) • Dissecting cellulitis of the scalp — recurrent painful, fluctuant dermal and subcutaneous nodules • Facial cellulitis in adults — a rare event. Patients usually develop pharyngitis, followed by high …

Candidiasis Mucocutaneous

Description of Medical Condition A mucocutaneous disorder caused by infection with various species of Candida. Candida is normally present, in very small amounts, in the oral cavity, gastrointestinal tract, and female genital tract. • Candida vulvovaginitis — infection on the vaginal mucosa, often associated with cutaneous vulvar involvement • Orophatyngeal candidiasis — infection of the oral cavity (“thrush”) and/or pharynx. • Candida esophagitis — usually associated with an immunosuppressed host • Gastrointestinal candidiasis — gastritis, sometimes with ulcers, usually associated with thrush. The small and large bowel can also be affected. • Angular cheilitis — fissures formed by Candida infection at the corners of the mouth. System(s) affected: Skin/Exocrine, Gastrointestinal Genetics: …

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Synonyms of Clotrimazole:

Chlotrimazole, Clotrimazol

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