Tags: Clofazimine

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Clofazimine is authorised in the world under the following brand names: Lampren, Lamprene.

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Other Mycobacteria

Essentials of Diagnosis Demonstration of the acid-fast bacillus. Infections more common in immunocompromised hosts. Infections mainly pulmonary or soft tissue. General Considerations The increasingly relative importance of the atypical mycobacteria, many of which are ubiquitous in the environment, was recognized with the decline in tuberculous disease. Generally, atypical mycobacteria are unusual causes of disease in patients who are immunocompetent but can in immunocompromised hosts such as AIDS and cancer patients. Most infections caused by atypical mycobacteria are skin and soft tissue abscesses, sometimes following pulmonary infection or implantation of prosthetic devices. There have been a few reports of epidemics of iatrogenic infection with atypical mycobacteria, associated with injection of contaminated materials. […]

Tuberculosis

Essentials of Diagnosis The cardinal symptoms of tuberculosis (TB) are fatigue, weight loss, fever, and night sweats. The most commonly infected populations include the homeless, institutionalized patients, and HIV-positive patients. In most cases, a TB skin test (PPD) is positive. To establish presence of infection, an acid-fast bacilli (AFB) smear demonstrates the acid-fast bacillus. In primary pulmonary TB, an infiltrate in the lower lobes of the lung is usually seen on chest x-ray. In contrast, apical lung infiltrates are commonly seen in the reactivation of pulmonary TB. General Considerations Mycobacterium tuberculosis is still an important pathogen. Approximately one-third of the world's population is infected with M tuberculosis, according to World Health […]

Buy No Prescription Lamprene (Clofazimine) 50mg

Clofazimine: Side Effects See also Antituberculosis drugs Clofazimine is weakly bactericidal against Mycobacterium leprae. It is active in chronic skin ulcers (Buruli ulcer) and partly against Mycobacterium avium intracellulare. The usual adult dosage is 50-100 mg/day. At higher doses, its anti-inflammatory effect seems to prevent the development of acute reactions, such as erythema nodosum leprosum. Clofazimine is a strongly lipophilic dye and accumulates in tissues, especially fat, bile, macrophages, the reticuloendothelial system, and skin. This is the basis of adverse reactions, including skin discoloration. Lymphedema, diminished sweating, and reduced tearing have been observed. Observational studies In 84 patients with leprosy who took clofazimine, the most common adverse effect was a dark […]

Order Clarithromycin (Biaxin) Without Prescription

Clarithromycin: Side Effects See also Macrolide antibiotics Clarithromycin is a commonly used macrolide antibiotic and is a regular part of regimens for the eradication of Helicobacter pylori, often in combination with a nitromidazole antibiotic as well, in addition to a proton pump inhibitor. Variable rates of adverse events (4-30%) have been reported with clarithromycin. Comparative studies In a double-blind, multicenter trial in 328 patients with H. pylori infection and non-ulcer dyspepsia, omeprazole 20 mg bd, amoxicillin 1 g bd, and clarithromycin 500 mg bd were compared with omeprazole alone. The rate of success and quality of life were similar in both groups. There were no serious adverse events. However, there were […]

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative […]

Toxicity of Antimicrobial Therapy

Mechanisms of toxicity The mechanisms associated with common adverse reactions to antimicrobials include dose-related toxicity that occurs in a certain fraction of patients when a critical plasma concentration or total dose is exceeded, and toxicity that is unpredictable and mediated through allergic or idiosyncratic mechanisms. For example, certain classes of drugs such as the aminoglycosides are associated with dose-related toxicity. In contrast, the major toxicity of the penicillins and cephalosporins is due to allergic reactions. These differences are explained in part by the relative ability of specific drugs to inhibit enzymatic pathways in the host versus their stimulation of specific immune response. Not included in these lists is mention of the […]

Dapsone (Aczone)

Dapsone, a synthetic sulfone, is an antimycobacterial and antiprotozoal agent. Cautions Hematologic Effects The most frequent adverse effects of dapsone are dose-related hemolytic anemia and methemoglobinemia. Hemolysis occurs in most patients receiving 200 mg or more of dapsone daily; however, symptomatic anemia occurs only occasionally. The manufacturer states that the hemoglobin level is generally decreased by 1-2 g/dL, the reticulocyte count is increased 2-12%, erythrocyte life span is shortened, and methemoglobinemia occurs in most patients receiving dapsone. Heinz body formation also occurs frequently. Unless severe, hemolysis or methemoglobinemia does not generally require discontinuance of dapsone therapy. These adverse hematologic effects occur in patients with or without glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, but […]

Dapsone (Aczone): Dosage and Administration

Administration Dapsone is administered orally. For administration to children, commercially available tablets of dapsone have been crushed and dissolved in strawberry syrup; however, studies evaluating bioavailability of the drug following administration of this preparation have not been published to date. Dosage Leprosy For the treatment of multibacillary leprosy, the World Health Organization (WHO) recommends that adults receive dapsone in a dosage of 100 mg daily in conjunction with rifampin (600 mg once monthly) and clofazimine (50 mg once daily and 300 mg once monthly) given for 12 months. Children 10-14 years of age with multibacillary leprosy should receive dapsone in a dosage of 50 mg daily in conjunction with rifampin (450 […]

Dapsone (Aczone): Uses

Leprosy Dapsone is used in rifampin-based multiple-drug regimens for the treatment of multibacillary and paucibacillary leprosy. Although dapsone was used alone in the past for the treatment of leprosy, the World Health Organization (WHO) and most clinicians currently recommend that rifampin-based multiple-drug regimens be used for the treatment of all forms of leprosy. Multiple-drug regimens may reduce infectiousness of the patient more rapidly as well as delay or prevent the emergence of resistant organisms. Rifampin-based regimens are necessary because of the increasing incidence of dapsone-resistant Mycobacterium leprae, and these regimens are designed to be effective against all strains of M. leprae, regardless of their susceptibility to dapsone. Because rifampin is bactericidal […]

Buy Lamprene (Clofazimine) Without Prescription 50mg

Clofazimine Clofazimine is a phenazine dye with antimycobacterial and anti-inflammatory activity. Administration Clofazimine is administered orally. Clofazimine should be taken with a meal to maximize absorption of the drug. Dosage Clofazimine dosages exceeding 100 mg daily should be given for as short a period as possible and only under close medical supervision. Leprosy The usual adult dosage of clofazimine for the treatment of leprosy is 50-100 mg once daily. Clofazimine also is given in a dosage regimen that includes 50 mg once daily plus an additional 300-mg dose given once monthly. Multibacillary Leprosy For the treatment of multibacillary leprosy, the World Health Organization (WHO) and other clinicians recommend that adults receive […]

Dosage forms of Clofazimine:
Clofazimine powder

Synonyms of Clofazimine:

Chlofazimine, Clofazimina [INN-Spanish], Clofaziminum [INN-Latin]

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Therapeutic classes of Clofazimine:

Antimycobacterials, Coloring Agents, Dyes, Leprostatic Agents

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