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Toxoplasma Gondii

General Considerations A. Epidemiology. Toxoplasma gondii infection, or toxoplasmosis, is a zoonosis (the definitive hosts are members of the cat family). The two most common routes of infection in humans are by oral ingestion of the parasite and by transplacental (congenital) transmission to the fetus. Ingestion of undercooked or raw meat that contains cysts or of water or food contaminated with oocysts results in acute infection. In humans, the prevalence of toxoplasmosis increases with age. There are also considerable geographic differences in prevalence rates (eg, 10% in Palo Alto, CA; 15% in Boston, MA; 30% in Birmingham, AL; 70% in France; = 90% in El Salvador). Differences in the epidemiology of …

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Toxoplasma Gondii: Treatment

A. Infection in Immunocompetent Adults and Children. Immunocompetent adults and children with toxoplasmic lymphadenitis do not require treatment unless symptoms are severe or persistent. Infections acquired by laboratory accident or transfusion of blood products are potentially more severe, and these patients should always be treated. The combination of pyrimethamine, sulfadiazine, and folinic acid for 4-6 weeks is the most commonly used and recommended drug regimen (Box 2). Treatment should be administered for 2-4 weeks, followed by reassessment of the patient’s condition. The decision to treat active toxoplasmic chorioretinitis should be based on the results of an examination performed by an ophthalmologist. Pyrimethamine and sulfadiazine plus folinic acid are commonly used for …

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Malaria and Babesia

PLASMODIUM SPP. Exposure history, such as travel, recent transfusion, or living in close proximity to an international airport. Nonfalciparum malaria: chills and fever spikes, followed by defervescence and fatigue; symptoms may be cyclic every 48-72 h. Falciparum malaria: fever spikes and chills, often noncyclic and associated with rapidly progressive systemic symptoms. Detection and identification of a Plasmodium species in a thick and thin blood smear, respectively. Molecular detection of P falciparum’s histidine-rich protein by enzyme-linked immunosorbent assay (ELISA) or Plasmodium DNA by polymerase chain reaction (PCR) followed speciation by probe hybridization or DNA sequencing. General Considerations A. Epidemiology. Malaria, a disease of antiquity, was recognized by Hippocrates and described possibly as …

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Babesia SPP.

Essentials of Diagnosis Nonspecific clinical manifestations. Exposure: tick exposure, blood transfusion, or both. Morphologic, serologic, or molecular evidence of infection. General Considerations The members of the genera Babesia and Theileria are protozoan parasites. These organisms are of medical, veterinary, and economic importance. Babesia species cause disease in humans and animals. The genus Theileria is the etiologic agent of cattle fever in Eurasia and Africa; it has also been implicated in human disease. Common to both genera is an intra-erythrocytic phase. These organisms develop pear-shaped intra-erythrocytic ring forms and are therefore referred to as piroplasms. An exo-erythrocytic schizont stage has been demonstrated only for Theileria species. Babesia species were first discovered in …

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Non-falciparum Malaria (P Vivax, P Ovale, P Malariae)

Clinical Findings A. Signs and Symptoms. Patients with nonfalciparum malaria invariably develop fever and chills that may become cyclic. Initially, patients experience chills, which are followed by fever (Box 1). Patients with malaria often manifest many nonspecific symptoms such as weakness, malaise, headache, and myalgias. As the disease progresses, signs of anemia, such as pale conjunctiva, may be seen. Splenomegaly and mild hepatomegaly may also be present. After hours of fever, defervescence occurs with marked diaphoresis. Patients are weakened and exhausted from the severity of the disease. In established infections caused by P vivax and P ovale, a periodicity may occur approximately every 48 h. P vivax and P ovale infections …

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Pneumocystis Carinii

Essentials of Diagnosis Pneumocystis carinii, when examined using molecular techniques, most closely resembles a fungus. Stains of either bronchoalveolar-lavage (BAL) or transbronchial-biopsy samples yield a diagnosis in > 90% of patients and should be considered the gold standard in diagnosis. BAL with transbronchial biopsy increases diagnostic yield to ~ 100%. P carinii has not yet been cultured in vitro. Polymerase chain reaction (PCR) (especially on sputum) increases sensitivity but reduces specificity. The prophylactic use of aerosolized pentamidine reduces the sensitivity of sputum and bronchoscopic samples. General Considerations A. Epidemiology. In 1983, P carinii pneumonia (PCP) was described as the AIDS-defining illness in = 60% of the first 1000 patients diagnosed with …

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Extrapulmonary P Carinii Infections

Extrapulmonary P carinii infections occur in < 3% of patients and must be diagnosed with histopathologic samples. Primary prophylaxis for PCP with pentamidine may confer a higher risk for extrapulmonary infection. Symptoms of extrapulmonary involvement are nonspecific, usually consisting of fevers, chills, and sweats. Although any area of the body may be involved, splenomegaly with cysts and thyroiditis are most common. Diagnosis The practice of diagnosing PCP morphologically by traditional staining methods (silver methenamine and toluidine blue) of induced sputum samples in HIV-infected individuals has fallen out of favor. Although relatively simple and inexpensive, staining of sputum samples induced by hypertonic saline inhalation is clearly dependent on operator and laboratory experience, …

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Mycoplasma & Ureaplasma

Mycoplasma and Ureaplasma species (mycoplasmas) are ubiquitous in nature and are commonly found in plants, animals, and humans. These bacteria contain the smallest amount of double-stranded DNA that is capable of producing a free-living microorganism; they measure between 0.15 and 0.3 um in diameter and = 2 um in length. They are believed to have evolved from a putative common ancestor of the gram-positive bacteria by a process of genome reduction and adoption of a dependent, parasitic life style. Mycoplasma and Ureaplasma spp. lack a cell wall. Therefore, they cannot be visualized with the Gram stain and are not susceptible to antibiotics that act on cell wall synthesis (eg, penicillins and …

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Actinomycetes

Actinomycetes are variably acid-fast, gram-positive bacilli that are sometimes filamentous and branched. Originally thought to be fungi due to their hyphae-like appearance, they are now recognized as bacteria based on their cell wall components, reproduction by fission without sporulation or budding, inhibition by antibacterial agents, and molecular phylogenetic analysis. The actinomycete chromosomes contain a high content of guanosine and cytosine. The actinomycetes include the genera Mycobacterium and Corynebacterium, which are discussed in site and site, respectively. The actinomycetes also include the genera Nocardia, Actinomyces, Rhodococcus, Tsukumurella, Gordona, Actinomadura, and Streptomyces, as well as the Whipple’s disease bacillus Tropheryma whippelii. Of these, members of the genus Nocardia are the most significant from …

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Actinomyces

Essentials of Diagnosis “Sulfur granules” in specimens and sinus tract drainage: hard, irregularly shaped, yellow particles measuring from 1 to 5 mm in size Gram-positive branching filaments arranged in ray-like projections under the microscope Colonies with characteristic “molar tooth” appearance Production of extensive fibrosis with “woody” induration No specific antibody or antigen detection tests General Considerations A. Epidemiology. The Actinomyces species are facultative anaerobes that commonly inhabit the oral cavity, the gastrointestinal tract, and the female genital tract, where they exist as commensals. Diversity within this genus is broad, which has led to taxonomic revision and reclassification of some species as members of the Arcanobacterium genus, eg, Actinomyces pyogenes. Disease occurs …

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Spanish And French Translations Of Common Medication Words:

English Spanish French
Medications Medicamentos Médicaments
Tablets Comprimidos Comprimés
Capsules Cápsulas Gélules
Pharmacies in the United States
Top 10 Pharmacy chains in the U. S. ranked by the number of pharmacists:
1 Walgreens 2 CVS 3 Walmart 4 Rite Aid 5 Kroger
6 Target 7 Kaiser Permanente 8 Sears 9 Cardinal Health 10 Dominick's
Pharmacy-led chains in the United Kingdom
Alliance Boots The Co-operative Lloyds Pharmacy
Numark Rowlands Pharmacy Superdrug

Synonyms of Clindamycin *:

Clindamicina [INN-Spanish], clindamycin, Clindamycin Hcl, Clindamycin Hydrochloride, Clindamycin Phosphate, Clindamycine [French], Clindamycine [INN-French], Clindamycinum [INN-Latin]

* Official titles and synonyms used in the British, European, and US Pharmacopoeias. INNs in the other main official languages (French, Latin, and Spanish) have also been included in the list of synonyms where these differ from the English INN.

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Dosage forms of Clindamycin:

Name, Strength, Form, Route
Clindamycin Capsule Oral
Clindamycin Cream Intravaginal
Clindamycin Cream Topical
Clindamycin Liquid Intramuscular
Clindamycin Liquid Intravenous
Clindamycin Powder, for solution Oral
Clindamycin Solution Intravenous
Clindamycin Solution Topical

Therapeutic classes of Clindamycin:

Anti-Bacterial Agents, Lincomycins, Protein Synthesis Inhibitors

Do I need a Prescription to buy Clindamycin in Online Pharmasy?
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Common brands (equivalents) of Clindamycin, which people buy in pharmacies of the world:

(The World's Largest Pharmaceutical Companies: Abbott, Amgen, AstraZeneca, Baxter, Bayer, Bristol-Myers Squibb, Boots, CSL, Eli Lilly, Forest, GlaxoSmithKline, Hoffmann - La Roche, Johnson & Johnson, Merck & Co., Mylan, Novartis, Pfizer (with Wyeth), Sanofi - Aventis, Sandoz, Solvay, Takeda, Teva, UCB, Watson)
(Australia, Canada, India, Mexico, New Zealand, USA, Europe [Belgium, France, Germany, Holland, Ireland, Spain, Switzerland, Great Britain (UK), Italy], and etc)
Apo-Clindamycin 300 mg Capsule Mylan-Clindamycin 300 mg Capsule Novo-Clindamycin 300 mg Capsule Dalacin C 150 mg Capsule
Clindets 1% pledgets Clindamycin hcl 150 mg capsule Clindamycin 2% vaginal cream Clindamax 2% vaginal cream
Clindamycin ph 300 mg/2 ml vial Cleocin t 1% gel Cleocin phos 150 mg/ml vial Cleocin 2% vaginal cream
Clindamycin 150 mg/ml addvan Dalacin C 300 mg Capsule Cleocin hcl 75 mg capsule Cleocin hcl 150 mg capsule
Clindamycin (60 & 120 Ml) 150 mg/ml Clindamycin 150 mg/ml Clindamycin phosphate 1% foam Clindamycin hcl 300 mg capsule
Dalacin C Phosphate 150 mg/ml Cleocin 150 mg capsule Clindagel 1% gel Evoclin 1% foam
Clindamycin phos crystals Cleocin hcl 300 mg capsule Clindamycin Phosphate 1% Solution 30ml Bottle Clindamycin phosphate powdr
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Clindamycin Phosphate 60 1% Swab Box Clindamycin Phosphate 2% Cream 40 gm Tube Cleocin-T 1% Gel 30 gm Tube Cleocin-T 1% Solution 60ml Bottle
Clindamycin Phosphate 1% Gel 60 gm Tube Clindamycin hcl crystals Cleocin 75 mg/5ml Solution 100ml Bottle Cleocin 3 100 mg Suppository Box
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