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Cefuroxime is authorised in the world under the following brand names: Ancef, Biofuroksym, Cedax, Cefizox, Cefobid, Cefotan, Ceftin, Cefurax, Cefuril, Cefzil, Cepazine, Cephuroxime, Duricef, Elobact, Kefurox, Kefzol, Kerurox, Mandol, Maxipime, Mefoxin, Monocid, Oraxim, Rocephin, Sharox, Velosef, Zinacef, Zinat, Zinnat.

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Specific Anti-Infective Agents

Antibiotics Before prescribing a specific antibiotic, clinicians should be able to answer these questions: •  How does the antibiotic kill or inhibit bacterial growth? •  What are the antibiotic’s toxicities and how should they be monitored? •  How is the drug metabolized, and what are the dosing recommendations? Does the dosing schedule need to be modified in patients with renal dysfunction? •  What are the indications for using each specific antibiotic? •  How broad is the antibiotic’s antimicrobial spectrum? •  How much does the antibiotic cost? Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in …

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative …

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Cefuroxime Axetil, Cefuroxime Sodium C16H16N4O8S • Cefuroxime is a semisynthetic, second generation cephalosporin antibiotic. Uses Cefuroxime axetil is used orally for the treatment of mild to moderate respiratory tract infections (i.e., acute maxillary sinusitis, acute exacerbations of chronic bronchitis, secondary infections of acute bronchitis, community-acquired pneumonia) caused by susceptible bacteria; acute bacterial otitis media; pharyngitis and tonsillitis caused by Streptococcus pyogenes (group A b-hemolytic streptococci); mild to moderate uncomplicated skin and skin structure infections caused by Staphylococcus aureus (including b-lactamase-producing strains) or S. pyogenes; and uncomplicated urinary tract infections caused by Escherichia coli or Klebsiella pneumoniae. Cefuroxime axetil also is used orally for the treatment of uncomplicated gonorrhea and for the …

Community-Acquired Pneumonia: Current Therapies

Overview Many highly effective agents are available for the treatment of bacterial community-acquired pneumonia (community-acquired pneumonia) and other community-acquire respiratory tract infections (RTIs). Currently marketed antibiotics for community-acquired pneumonia demonstrate similar efficacy rates in clinical trials, and these agents have generally achieved clinical symptom resolution in 85-95% of trial participants. The drugs differ mainly in their spectrum of activity (the organisms against which the agent is effective), side-effect profiles, dosing schedules, and dose form availability. Broad-spectrum antibiotics are effective against a wide range of pathogens; narrow-spectrum antibiotics tend to be efficacious against a narrower range of bacterial species, generally either gram-positive or gram-negative organisms.TABLE:Mechanisms of Resistance Against Select Antibacterial Classes, 2004 …

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Cefuroxime Axetil. Cefprozil Cefuroxime Axetil Cefuroxime axetil (GSK’s Ceftin/Zinnat/Oracef) is a second-generation cephalosporin consisting of an esterified pro-drug of cefuroxime created for oral formulation; the active antibiotic metabolite cefuroxime is released after cefuroxime axetil absorption from the gastrointestinal tract. First launched in the United States in 1988, cefuroxime axetil was available as a generic in the United States by 2002. Cefuroxime is active against a broad spectrum of gram-positive and gram-negative bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, E. coli, H. influenzae, K. pneumoniae, and M. catarrhalis. Cefuroxime axetil is indicated for a number of bacterial infections, including RTIs caused by β-lactam  ase-negative strains of S. pneumoniae, H. influenzae, M. …

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Cefuroxime Axetil. Cefprozil. Cefpodoxime Proxetil Cefuroxime Axetil Cefuroxime axetil (GlaxoSmithKline’s Ceftin/Zinnat/ Oracef) * is a second-generation oral cephalosporin consisting of an esterified pro-drug of cefuroxime; the active antibiotic metabolite cefuroxime is released following cefuroxime axetil absorption from the GI tract. First launched in the United States in 1988, cefuroxime axetil was available as a U.S. generic by 2002. This product is active against a broad spectrum of gram-positive and gram-negative bacteria, including S. pneumoniae, H. influenza, K. pneumoniae, and M. catarrhalis. Cefuroxime axetil is indicated for a number of bacterial infections including respiratory tract infections caused by β-lactamase-negative strains of S. pneumoniae, H. influenzae, M. catarrhalis, and Haemophilusparainfluenzae. The agent’s efficacy …


Overview The penicillins comprise several subgroups of agents with a wide range of bacterial coverage and efficacy. Each penicillin molecule contains a basic β-lactam structure fused to a five-membered ring. Because of their broad spectrum of activity and availability in oral form, the penicillins are commonly used in the treatment of acute exacerbations of chronic bronchitis and have become the drugs of choice in treating many common infections. The penicillins are further divided into the following groups: natural penicillins, aminopenicillins, and the extended-spectrum penicillins. The natural penicillins (e.g., penicillin G) have the narrowest spectrum. They are active only against the gram-positive cocci and, with regard to acute exacerbations of chronic bronchitis, …

Acute Exacerbations of Chronic Bronchitis: Current therapies

Overview Numerous highly effective pharmacological agents are available to treat acute exacerbations of chronic bronchitis (acute exacerbations of chronic bronchitis). TABLE:Pharmacological Management of Underlying Disease During an Acute Exacerbation of Chronic Bronchitis summarizes the general pharmacological agents and classes used to manage acute exacerbations of chronic bronchitis. The primary therapies used in acute exacerbations of chronic bronchitis treat the causative infection (antibiotics), relieve symptoms (bronchodilators), and treat the underlying inflammation (corticosteroids). TABLE :Current Therapies Used for Acute Exacerbations of Chronic Bronchitis summarizes the leading antibiotic therapies used to treat the infection. Most acute exacerbations of chronic bronchitis cases require empiric antibiotic therapy because of the difficulty in definitively distinguishing exacerbations of …

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Zinacef (Cefuroxime) 750mg and 250mg Tablets Read all of this leaflet carefully before you start taking this medicine. •   Keep this leaflet. You may need to read it again. •   If you have any further questions, ask your doctor or pharmacist. •  This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours. •   If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. What Zinacef is and what it is used for Read indications for use if you …

Antibiotics and helpful bacteria

Question from John of New Hampshire, USA I am on an antibiotic called CEFTIN. It lists side effects about losing certain bacteria you need in you system, but does not tell you what to do to get it back. Dear John: Antibiotics can kill many of the helpful bacteria as well as the harmful ones, leading to such side effects as thrush (yeast in the mouth), vaginal yeast, and diarrhea. These side effects are often self limited (when the antibiotic is stopped and your own “good” bacteria regrow over several days naturally), however, specific treatments may be needed in cases where abnormal bacteria dominate and can even involve another antibiotic.

Dosage forms of Cefuroxime:
Apo-Cefuroxime 250 mg Tablet Ratio-Cefuroxime 250 mg Tablet Velosef 250 mg capsule Ceftin 250 mg Tablet
Velosef 500 mg capsule Apo-Cefuroxime 500 mg Tablet Ratio-Cefuroxime 500 mg Tablet Cefuroxime axetil 250 mg tablet
Ceftin 500 mg Tablet Cefzil 250 mg tablet Duricef 1 gm tablet Cefuroxime axetil 500 mg tablet
Cefzil 500 mg tablet Ceftin 250 mg tablet Cefuroxime sod 1.5 gm vial Zinacef 1.5 gm vial
Zinacef 1.5 gm add-vant vial Cedax 400 mg capsule Cefuroxime 1.5 g/50 ml bag Ceftin 500 mg tablet
Maxipime 1 gram vial Duricef 250 mg/5ml Suspension 50ml Bottle Maxipime 1 gm piggyback vial Velosef 250 mg/5ml Suspension 100ml Bottle
Maxipime 2 gram vial Duricef 500 mg/5ml Suspension 75ml Bottle Cefzil 125 mg/5ml Suspension 100ml Bottle Duricef 500 mg/5ml Suspension 100ml Bottle
Rocephin 1 gm vial Rocephin 1 gm Solution Vial Zinacef 7.5 gm vial Cefzil 250 mg/5ml Suspension 100ml Bottle
Rocephin 2 gm vial Cefuroxime Axetil 250 mg/5ml Suspension 100ml Bottle Ceftin 20 500 mg tablet Bottle Rocephin 10 gm vial
Zinacef-water 1.5 gm/50 ml      

Synonyms of Cefuroxime:

Cefuroxim, Cefuroxime [USAN:BAN:INN], Cefuroximo [INN-Spanish], Cefuroximum [INN-Latin]

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Therapeutic classes of Cefuroxime:

Anti-Bacterial Agents, Cephalosporins

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