Tags: Cefizox

Specific Anti-Infective Agents

Antibiotics Before prescribing a specific antibiotic, clinicians should be able to answer these questions: •  How does the antibiotic kill or inhibit bacterial growth? •  What are the antibiotic’s toxicities and how should they be monitored? •  How is the drug metabolized, and what are the dosing recommendations? Does the dosing schedule need to be modified in patients with renal dysfunction? •  What are the indications for using each specific antibiotic? •  How broad is the antibiotic’s antimicrobial spectrum? •  How much does the antibiotic cost? Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in …

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Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative …

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Ceftizoxime Sodium

• Ceftizoxime is a semisynthetic, third generation cephalosporin antibiotic. Uses Ceftizoxime is used for the treatment of bone and joint infections, intra-abdominal infections, meningitis, lower respiratory tract infections, septicemia, skin and skin structure infections, and urinary tract infections caused by susceptible bacteria. The drug also is used for the treatment of gonorrhea and pelvic inflammatory disease.In addition, ceftizoxime has been used for perioperative prophylaxis. Prior to initiation of ceftizoxime therapy, appropriate specimens should be obtained for identification of the causative organism and in vitro susceptibility tests. Ceftizoxime therapy may be started pending results of susceptibility tests but should be discontinued if the causative organism is found to be resistant to the …

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Cephalosporins: Ceftizoxime

Overview. Cephalosporins have traditionally been one of the most commonly used antibacterial classes for the treatment of respiratory tract infections. In recent years, drug development within this class has been limited owing to competitiveness, the lack of novel candidates, and high development costs relative to return. Cephalosporins differ widely in their spectrum of activity, susceptibility to β-lactamases produced by bacteria, and serum half-life. These agents are highly successful agents for the treatment of RTI; however, they need to be combined with a macrolide for coverage of atypical organisms (e.g., such as Mycoplasma). Dong-A pharmaceuticals in South Korea is developing DA-7101, indicated for the potential treatment of respiratory and urinary tract infections. …

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