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Cefixime is authorised in the world under the following brand names: Cefixoral, Cefspan, Cephoral, CFIX, Oroken, Suprax, Unixime.

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Neisseria Meningitidis

Essentials of Diagnosis • Transmission in crowded or closed populations. • Meningitis most common, but bacteremia, pneumonia, and other syndromes can occur in absence of meningitis. • Disease often associated with petecchial or purpuric rash, which may involve palms and soles. • Neutrophil-predominant cell profile in CSF, with low-glucose and high-protein concentrations. • Gram-negative diplococci inside neutrophils on stained smears of CSF and aspirated skin lesions. • Fastidious organism requires special media and growth conditions. • Blood and CSF most useful specimens for recovery of organism. • Improved sensitivity of detection with PCR in CSF, but not widely available. General Considerations A. Epidemiology. N meningitidis is found only in humans and …

Streptococcus Pyogenes

Essentials of Diagnosis • Pharyngitis: presence of sore throat, submandibular adenopathy, fever, pharyngeal erythema, exudates. • Rheumatic fever: migratory arthritis, carditis, Syndenham’s chorea, pharyngitis. • Cellulitis: pink skin, fever, tenderness, swelling. • Scarlet fever: sandpaper-like erythema, strawberry tongue, streptococcal pharyngitis or skin infection, high fever. • Post-streptococcal glomerulonephritis: acute glomerulonephritis (hematuria, proteinuria) following pharyngitis or impetigo. • Impetigo: dry, crusted lesions of the skin, weeping golden-colored fluid. • Erysipelas: salmon red rash of face or extremity, well-demarcated border, fever, occasionally bullous lesions. • Streptococcal toxic shock syndrome: isolation of Group A streptococcus from a normally sterile site, sudden onset of shock and organ failure. • Necrotizing fasciitis, myonecrosis: deep, severe pain, …

Specific Causes Of Acute Community-Acquired Pneumonia

Great overlap occurs among the clinical manifestations of the pathogens associated with acute community-acquired pneumonia. However, constellations of symptoms, signs, and laboratory findings serve to narrow the possibilities. By developing an ability to focus on a few pathogens or to identify a specific pathogen, clinicians can better predict the clinical course of pneumonia and can narrow antibiotic coverage. Streptococcus pneumoniae Pathogenesis Pathogenic strains of S. pneumoniae have a thick capsule that prevents PMN binding and that blocks phagocytosis. Certain capsular types (1, 3, 4, 7, 8, and 12 in adults, and 3, 6, 14, 18, 19, and 23 in children) account for most pneumonia cases. Type 3 has the thickest polysaccharide …

Anti-Infective Agent Dosing

The characteristics that need to be considered when administering antibiotics include absorption (when dealing with oral antibiotics), volume of distribution, metabolism, and excretion. These factors determine the dose of each drug and the time interval of administration. To effectively clear a bacterial infection, serum levels of the antibiotic need to be maintained above the minimum inhibitory concentration for a significant period. For each pathogen, the minimum inhibitory concentration is determined by serially diluting the antibiotic into liquid medium containing 104 bacteria per millihter. Inoculated tubes are incubated overnight until broth without added antibiotic has become cloudy or turbid as a result of bacterial growth. The lowest concentration of antibiotic that prevents …

Specific Anti-Infective Agents

Antibiotics Before prescribing a specific antibiotic, clinicians should be able to answer these questions: •  How does the antibiotic kill or inhibit bacterial growth? •  What are the antibiotic’s toxicities and how should they be monitored? •  How is the drug metabolized, and what are the dosing recommendations? Does the dosing schedule need to be modified in patients with renal dysfunction? •  What are the indications for using each specific antibiotic? •  How broad is the antibiotic’s antimicrobial spectrum? •  How much does the antibiotic cost? Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in …

Urinary Tract Infections and Prostatitis

Definition Infections of the urinary tract represent a wide variety of clinical syndromes including urethritis, cystitis, prostatitis, and pyelonephritis. A urinary tract infection is defined as the presence of microorganisms in the urine that cannot be accounted for by contamination. The organisms have the potential to invade the tissues of the urinary tract and adjacent structures. Lower tract infections include cystitis (bladder), urethritis (urethra), prostatitis (prostate gland), and epididymitis. Upper tract infections involve the kidney and are referred to as pyelonephritis. Uncomplicated urinary tract infections are not associated with structural or neurologic abnormalities that may interfere with the normal flow of urine or the voiding mechanism. Complicated urinary tract infections are …


The causative organism of syphilis is Treponema pallidum, a spirochete. Syphilis is usually acquired by sexual contact with infected mucous membranes or cutaneous lesions, although on rare occasions it can be acquired by nonsexual personal contact, accidental inoculation, or blood transfusion. Clinical presentation The clinical presentation of syphilis is varied, with progression through multiple stages possible in untreated or inadequately treat patients (Table Presentation of Syphilis Infections). Primary Syphilis Primary syphilis is characterized by the appearance of a chancre on cutaneous or mucocutaneous tissue. Chancres persist only for 1 to 8 weeks before spontaneously disappearing. TABLE. Treatment of Gonorrhea Type of Infection Recommended Regimensa Alternative Regimensb Uncomplicated infections of the cervix, …

Respiratory Tract Infections, Upper

Otitis media Definition Otitis media is an inflammation of the middle ear. Acute otitis media involves the rapid onset of signs and symptoms of inflammation in the middle ear that manifests clinically as one or more of the following: otalgia (denoted by pulling of the ear in some infants), hearing loss, fever, or irritability. Otitis media with effusion (accumulation of liquid in the middle ear cavity) differs from acute otitis media in that signs and symptoms of an acute infection are absent. Otitis media is the most frequent diagnosis in infants and children. Risk factors contributing to increased incidence of otitis media include the winter season, attendance at a day care …

Respiratory Tract Infections, Lower

Lower respiratory tract infections include infectious processes of the lungs and bronchi, pneumonia, bronchitis, bronchiolitis, and lung abscess. Bronchitis Acute bronchitis Bronchitis refers to an inflammatory condition of the large elements of the tracheobronchial tree that is usually associated with a generalized respiratory infection. The inflammatory process does not extend to include the alveoli. The disease entity is frequently classified as either acute or chronic. Acute bronchitis most commonly occurs during the winter months. Cold, damp climates and/or the presence of high concentrations of irritating substances such as air pollution or cigarette smoke may precipitate attacks. Pathophysiology Respiratory viruses are by far the most common infectious agents associated with acute bronchitis. …

Bacterial Infections

The bacterial species most commonly associated with gastrointestinal infection and infectious diarrhea in the United States are Shigella spp., Salmonella spp., Campylobacter spp., Yersinia spp., Escherichia spp., Clostridium spp., and Staphylococcus spp. Antibiotics are not essential in the treatment of most mild diarrheas, and empirical therapy for acute gastrointestinal infections may result in unnecessary antibiotic courses. Enterotoxigenic (cholera-like) Diarrhea Cholera (Vibrio cholerae) Vibrio cholerae is the organisms that most often causes human epidemics and pandemics. Four mechanisms for transmission have been proposed: animal reservoirs, chronic carriers, asymptomatic or mild disease victims, or water reservoirs. TABLE. Clinical Assessment of Degree of Dehydration in Children Based on Percentage of Body Weight Lossa Variable …

Dosage forms of Cefixime:
Suprax 100 mg/5ml Suspension Suprax 400 mg Tablet Suprax 20 mg/ml Suspension

Synonyms of Cefixime:

Cefixim, Cefixima [Spanish], Cefixime Anhydrous, Cefiximum [Latin]

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Therapeutic classes of Cefixime:

Anti-Bacterial Agents, Cephalosporins

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