Tags: Ancobon

Antifungal Agents

Fungi are eukaryotes, and they share many of the structural and metabolic characteristics of human cells. As a result, designing agents that affect fungi without harming human cells has proved difficult. One major difference between the two cell types is the primary sterol building block used to form the plasma membrane. The fungal plasma membrane consists of ergosterols; the major sterol component of the human plasma membrane is cholesterol. This difference has been exploited in the development of two classes of drugs. The polyenes act by binding to ergosterol and disrupting the fungal membrane. These agents are fungicidal. The azoles inhibit ergosterol synthesis, and lowered ergosterol levels results in fungal membrane […]

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials. Determinants of Antimicrobial Efficacy Measurement of antimicrobial activity in vitro Susceptibility testing is indicated for any bacterial pathogen warranting chemotherapy. Drugs that irreversibly destroy the ability of an organism to replicate, and perhaps in the process destroy the structural integrity of the organism, are microbicidal. Drugs that reversibly impair replicating ability, with this function being restored when drug concentrations fall below critical inhibitory levels, are microbiostatic. In quantitative […]

Flucytosine (Ancobon 250, 500mg)

Flucytosine, a fluorinated pyrimidine analog, is a synthetic antifungal agent. Uses Oral flucytosine is used for the treatment of serious infections caused by susceptible strains of Candida or Cryptococcus neoformans and for the treatment of chromomycosis (chromoblastomycosis) caused by susceptible fungi. While flucytosine may be effective when used alone for the treatment of some fungal infections (e.g., candidal cystitis, chromomycosis), the drug should not be used alone in the treatment of severe, life-threatening infections. In the treatment of serious candidal or cryptococcal infections, flucytosine generally has been used as an adjunct to IV amphotericin B or an azole antifungal agent (e.g., fluconazole, itraconazole). Use of flucytosine in conjunction with amphotericin B […]

Flucytosine

Drug Nomenclature Synonyms: 5-FC; Flucitosina; Flucitozin; Flucitozinas; Flucytosin; Flucytosinum; Flusytosiini; Ro-2-9915 BAN: Flucytosine USAN: Flucytosine INN: Flucytosine [rINN (en)] INN: Flucitosina [rINN (es)] INN: Flucytosine [rINN (fr)] INN: Flucytosinum [rINN (la)] INN: Флуцитозин [rINN (ru)] Chemical name: 5-Fluorocytosine; 4-Amino-5-fluoropyrimidin-2(1H)-one Molecular formula: C4H4FN3O =129.1 CAS: 2022-85-7 ATC code: D01AE21; J02AX01 Read code: y02U8 Pharmacopoeias in China, Europe, International, Japan, and US European Pharmacopoeia, 6th ed. (Flucytosine) A white or almost white crystalline powder. Sparingly soluble in water slightly soluble in dehydrated alcohol. Protect from light. The United States Pharmacopeia 31, 2008 (Flucytosine) A white to off-white crystalline powder, odourless or with a slight odour. Sparingly soluble in water slightly soluble in alcohol practically […]

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