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C Trachomatis Infections

Essentials of Diagnosis • Typical intracytoplasmic inclusions in Giemsa-stained cell scrapings from the conjunctiva. • Ligase chain reaction (LCR) or polymerase chain reaction (PCR) in first-void urine. • Positive culture in McCoy or HeLa cells of body fluids or secretions. • Positive microimmunofluorescence serology for suspected cases of lymphogranuloma venereum and infants with pneumonia. • Complement fixation titer of 1:64 or greater in patients with presumed lymphogranuloma venereum. Clinical Syndromes C trachomatis is associated with urethritis, proctitis, conjunctivitis, and arthritis in women and men; epididymitis in men; and mucopurulent cervicitis (MPC), acute salpingitis, bartholinitis, and the Fitz-Hugh and Curtis syndrome in women (Box 1). C trachomatis and Neisseria gonorrhoeae (see site) …

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Borrelia & Leptospira Species

 BORRELIA SPECIES RELAPSING FEVER Essentials of Diagnosis • The most common presentation is fever with rash, headache, shaking chills, myalgias, arthralgias, and — during the acute phase — hepatosplenomegaly. • Louse-borne relapsing fever (LBRF) is epidemic, caused by B. recurrentis, and characterized by one or two relapses. • Tick-borne relapsing fever (TBRF) is endemic, caused by several Borrelia species, and characterized by multiple clinical relapses. • Organisms can be visualized in blood smears of febrile patients, unlike other spirochetal pathogens, using dark-field microscopy or Giemsa or Wright stains. • Helical (3-10 spirals) spirochetes, 8-30 um × 0.3 um, motile (flagella). • Weil-Felix reaction: Proteus OX-K agglutinin titers are elevated (this is …

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Lyme Disease

Essentials of Diagnosis • Most common in the northeastern, upper midwestern, and western parts of the United States. • Borrelia burgdorferi is the longest (20-30 um) and narrowest (0.2-0.3 um) spirochete member of the Borrelia genus and has the fewest flagella (7-11). • Erythema migrans (EM) is a red expanding lesion with central clearing that is commonly seen during the early stage of Lyme disease. • The most common systems affected are the skin (EM), the joints (arthritis), the CNS (facial palsy), and the heart (conduction defects). • Serology is not standardized; it is insensitive in early infection and does not distinguish active from inactive infection. • Grows in Barbour-Stoenner-Kelly medium …

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Actinomycetes

Actinomycetes are variably acid-fast, gram-positive bacilli that are sometimes filamentous and branched. Originally thought to be fungi due to their hyphae-like appearance, they are now recognized as bacteria based on their cell wall components, reproduction by fission without sporulation or budding, inhibition by antibacterial agents, and molecular phylogenetic analysis. The actinomycete chromosomes contain a high content of guanosine and cytosine. The actinomycetes include the genera Mycobacterium and Corynebacterium, which are discussed in site and site, respectively. The actinomycetes also include the genera Nocardia, Actinomyces, Rhodococcus, Tsukumurella, Gordona, Actinomadura, and Streptomyces, as well as the Whipple’s disease bacillus Tropheryma whippelii. Of these, members of the genus Nocardia are the most significant from …

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Nocardia

Essentials of Diagnosis • Gram-positive, variably acid-fast, branching filaments with aerial hyphae. • Colonies have characteristic chalky-white or cotton ball appearance. • Suspect when chronic pulmonary disease is accompanied by CNS or skin lesions. • No specific antibody or antigen detection tests. General Considerations A. Epidemiology. Nocardia spp. are strictly aerobic, ubiquitous soil-dwelling organisms that are largely responsible for the decomposition of organic plant material. Infection usually occurs via inhalation of these organisms in airborne dust particles, leading to pulmonary disease. However, infection can also be acquired via direct percutaneous inoculation by thorns, animal scratches, bites, surgical wounds, and intravenous catheters. Dissemination commonly occurs to the central nervous system (CNS), skin, …

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Brucella, Francisella, Pasteurella, Yersinia, & Hacek

BRUCELLOSIS Essentials of Diagnosis • Suspected in patients with chronic fever of unknown etiology who have a history of occupational exposure or come from a high prevalence area. • Leukopenia. • Blood culture or bone marrow cultures on appropriate media. • Serum antibody titer = 1:160. • Polymerase chain reaction. General Considerations Brucellosis (also called undulant fever, Mediterranean fever, Malta fever) is an infection that causes abortion in domestic animals. It is caused by one of six species of Brucella coccobacilli. It may occasionally be transmitted to humans, in whom the disease could be acute or chronic with ongoing fever and constitutional symptoms without localized findings. A. Epidemiology. Brucellosis is transmitted …

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Pasteurella

Essentials of Diagnosis • History of a cat or dog bite or other exposure. • Pain, erythema, swelling, and drainage at the bite site. • Gram-negative bipolar bacilli on Gram stain of the drainage. • Culture of the organism confirms the diagnosis. General Considerations Pasteurella multocida infection, a disease that primarily affects animals, may occasionally affect humans, causing a wide variety of infections ranging from soft tissue infection to bacteremia and endocarditis. A. Epidemiology. Pasteurella multocida has been recovered from cultures of specimens from the nasopharynx and the gastrointestinal tract of a large number of asymptomatic wild and domestic animals. The highest carriage rates occur in cats (50%-90%), dogs or swine …

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Important Anaerobes

Essentials of Diagnosis • Foul odor of draining purulence. • Presence of gas in tissues. • No organism growth on aerobic culture media. • Infection localized in the proximity of mucosal surface. • Presence of septic thrombophlebitis. • Tissue necrosis and abscess formation. • Association with malignancies (especially intestinal). • Mixed organism morphologies on Gram stain. General Considerations A. Epidemiology and Ecology. Anaerobic bacteria are the predominant component of the normal microbial flora of the human body. The following sites harbor the vast majority of them: • Skin: Mostly gram-positive bacilli such as Propionibacterium acnes • Gastrointestinal tract: In the oral cavity Prevotella spp., Porphyromonas spp., Peptostreptococcus spp., microaerophillic streptococci, and …

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Toxin-Mediated Infections

1. TETANUS Tetanus is a disease of global incidence produced by the toxin of Clostridium tetani. The risk of acquiring it increases in people > 60 years of age and in neonates, especially in Third World countries where poor sanitary conditions predispose to umbilical stump contamination. Immunization campaigns have played a crucial role in bringing about the observed decreasing incidence in the United States. The pathogenesis of tetanus involves the absorption of preformed toxin, or, less commonly, invasion of toxin-producing organisms from contaminated wounds; it may complicate surgical wounds colonized with C tetani. Incubation periods vary depending on the portal of entry. The toxin tetanospasmin blocks the transmission of inhibitory neurons, …

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Haemophilus, Bordetella, & Branhamella Species

HAEMOPHILUS INFLUENZAE & OTHER HAEMOPHILUS SPECIES Essentials of Diagnosis • Haemophilus influenzae is generally acquired via the aerosol route or by direct contact with respiratory secretions. • The most common associated syndromes include otitis media, sinusitis, conjunctivitis, bronchitis, pneumonia, and, to a lesser extent, meningitis, epiglottitis, arthritis, and cellulitis. • Gram stain shows pleomorphic gram-negative coccobacilli. • In cases of meningitis, epiglottitis, arthritis, and cellulitis, organisms are typically recovered from blood, and type-b polysaccharide capsular material may be detected in the urine. • Organisms and type-b polysaccharide capsule may also be present in other appropriate sterile body fluids, such as cerebrospinal fluid (CSF) in meningitis and joint fluid in arthritis. General …

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Spanish And French Translations Of Common Medication Words:

English Spanish French
Medications Medicamentos Médicaments
Tablets Comprimidos Comprimés
Capsules Cápsulas Gélules
Pharmacies in the United States
Top 10 Pharmacy chains in the U. S. ranked by the number of pharmacists:
1 Walgreens 2 CVS 3 Walmart 4 Rite Aid 5 Kroger
6 Target 7 Kaiser Permanente 8 Sears 9 Cardinal Health 10 Dominick's
Pharmacy-led chains in the United Kingdom
Alliance Boots The Co-operative Lloyds Pharmacy
Numark Rowlands Pharmacy Superdrug

Synonyms of Amoxicillin *:

AMC, Amoxicilina [INN-Spanish], Amoxicillin anhydrous, Amoxicillin Trihydrate, Amoxicilline [INN-French], Amoxicillinum [INN-Latin], Amoxycillin, Amoxycillin Trihydrate, D-Amoxicillin, p-Hydroxyampicillin

* Official titles and synonyms used in the British, European, and US Pharmacopoeias. INNs in the other main official languages (French, Latin, and Spanish) have also been included in the list of synonyms where these differ from the English INN.

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Dosage forms of Amoxicillin:

Name, Strength, Form, Route
Amoxicillin Capsule Oral
Amoxicillin Powder, for solution Oral
Amoxicillin Powder, for suspension Oral
Amoxicillin Suspension Oral
Amoxicillin Tablet Oral

Therapeutic classes of Amoxicillin:

Anti-Bacterial Agents, Penicillins

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Common brands (equivalents) of Amoxicillin, which people buy in pharmacies of the world:

(The World's Largest Pharmaceutical Companies: Abbott, Amgen, AstraZeneca, Baxter, Bayer, Bristol-Myers Squibb, Boots, CSL, Eli Lilly, Forest, GlaxoSmithKline, Hoffmann - La Roche, Johnson & Johnson, Merck & Co., Mylan, Novartis, Pfizer (with Wyeth), Sanofi - Aventis, Sandoz, Solvay, Takeda, Teva, UCB, Watson)
(Australia, Canada, India, Mexico, New Zealand, USA, Europe [Belgium, France, Germany, Holland, Ireland, Spain, Switzerland, Great Britain (UK), Italy], and etc)
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