Prescription Drugs

Itraconazole 100 mg Capsules (Sporanox)

Itraconazole is a synthetic dioxolane triazole compound. Itraconazole: Mechanism of action Like other azoles, it interferes with the cytochrome P-450-dependent enzyme, 14a-demethylase. This leads to 14-methylsterol accumulation and ergosterol depletion in fungal cells and this results in alterations in a number of membrane-associated cell functions. Itraconazole: Spectrum of action Itraconazole has a broad spectrum of action including Aspergillus species, Blastomyces dermatitidis, Candida species, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Paracoccidioides brasiliensis, Scedosporium apiospermum and Sporothrix schenckii. It is active in dermatophytosis and pityriasis versicolor, but appears to be ineffective in mucormycosis. Itraconazole: Acquired resistance This is rare, but ketoconazole-resistant C. albicans strains from patients with chronic mucocutaneous candidosis have been cross-resistant …

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Use and Administration of Itraconazole 100 mg (Sporanox)

Therapeutic use of Itraconazole 100 mg Capsules (Sporanox) Itraconazole can be used to treat various superficial fungal infections, including the dermatophytoses, pityriasis versicolor, and mucosal and cutaneous forms of candidosis. It is also effective in patients with subcutaneous infections, such as chromoblastomycosis, sporotrichosis and certain forms of phaeohyphomycosis. It has become the drug of choice for non-life-threatening forms of blastomycosis and histoplasmosis, and is a useful alternative to amphotericin B for invasive aspergillosis. Maintenance treatment with itraconazole has helped to prevent relapse in patients with AIDS with histoplasmosis or cryptococcosis, and prophylactic treatment with this drug has helped to prevent aspergillosis and candidosis in neutropenic patients. However, it has not been …

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Pharmacokinetics of Itraconazole 100 mg Capsules (Sporanox)

Absorption of itraconazole from the gastrointestinal tract is incomplete (about 55%), but is improved if the drug is given with food. Oral administration of a single 100-mg capsule will produce peak serum concentrations of between 0.1 and 0.2mg/l about 2-4 h later. Higher concentrations are obtained after repeated dosing, but there is marked variation between individuals. As with ketoconazole, there is a disproportionate increase in blood levels with increasing dosage. Serum concentrations are markedly reduced when gastric acid production is impaired. Much higher blood concentrations (up to 1.0-1.5 mg/1) have been attained in patients with AIDS and neutropenic individuals following administration of a 5 mg/kg dose of the oral solution formulation …

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Griseofulvin 250 mg Tablets (Grifulvin)

Griseofulvin is an antifungal antibiotic derived from a number of Penicillium species. It was the first oral drug for treatment of dermatophytosis. Mechanism of action Griseofulvin is a fungistatic drug which binds to microtubular proteins and inhibits fungal cell mitosis. It also acts as an inhibitor of nucleic acid synthesis. Griseofulvin: Spectrum of action Griseofulvin has a limited spectrum of action which is almost restricted to the dermatophytes (Epidermophyton floccosum, Microsporum species and Trichophyton species). Its clinical use is limited to these infections. It is ineffective in cutaneous candidosis and pityriasis versicolor. Acquired resistance Treatment failure attributable to the development of griseofulvin resistance is an uncommon problem in patients with dermatophytoses. …

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Fluconazole 50, 100, 150, 200 mg Tablets (Diflucan)

Fluconazole Fluconazole is a synthetic bis-triazole compound. Fluconazole (Diflucan): Mechanism of action Fluconazole is a potent inhibitor of ergosterol biosynthesis, through its action on the cytochrome P-450-dependent enzyme, lanosterol 14a-demethylase. Depletion of ergosterol, the principal sterol in the membrane of susceptible fungal cells, and accumulation of methylated sterols leads to alterations in a number of membrane-associated cell functions. Fluconazole (Diflucan): Spectrum of action Fluconazole has a broad spectrum of action including Blastomyces dermatitidis, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum and Paracoccidioides brasiliensis. It is active against Candida albicans, C. tropicalis and C. parapsilosis, but many strains of C. krusei and Torulopsis glabrata (now reclassified as Candida glabrata) appear to be insensitive. …

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Use and Administration of Fluconazole 50, 100, 150, 200 mg Tablets (Diflucan)

Therapeutic Use of Fluconazole 50, 100, 150, 200 mg Tablets (Diflucan) Fluconazole can be used to treat mucosal and cutaneous forms of candidosis. It is also effective in various forms of dermatophytosis and pityriasis versicolor. It is a promising drug for treatment of deep forms of candidosis in patients without neutropenia, but should not be used as first-line treatment in neutropenic patients unless there are particular reasons for favouring it against established management. Fluconazole has proved to be a useful prophylactic treatment against candidosis in neutropenic patients. However, it is ineffective in aspergillosis and mucormycosis. Fluconazole is a useful drug in acute cryptococcal meningitis, but should not be used as first-line …

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Drug Interactions of Fluconazole 50, 100, 150, 200 mg Tablets (Diflucan)

Most drug interactions with azole antifungals occur by means of one of two basic mechanisms: impairment of the absorption of the azole compound leading to reduced blood concentrations; or interference with hepatic microsomal enzymes which alters the metabolism and blood concentrations of the azole, the interacting drug, or both. Unlike itraconazole and ketoconazole, absorption of fluconazole is not reduced if it is given together with drugs that reduce gastric acid secretion. Concomitant administration of fluconazole and rifampicin has resulted in a modest reduction in blood levels of the antifungal agent. The effect is less marked than with itraconazole or ketoconazole and is due to induction of P-450 cytochrome oxidases by rifampicin …

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Clarithromycin 125mg/5ml Oral Suspension

Generic Name:¬†Clarithromycin Information For The User 1. What Clarithromycin 125mg/5ml Oral Suspension Is And What It Is Used For Clarithromycin 125mg/5ml oral suspension contains clarithromycin. Clarithromycin belongs to a group of antibiotics called macrolides. Clarithromycin works by destroying some types of bacteria that cause certain infections. Clarithromycin may be used to treat infections that are caused by bacteria in the chest, throat, sinuses and ear and infections of the skin and the layers of flesh just under the skin. Clarithromycin 125mg/5ml oral Suspension is used in children 6 months to 12 years old. 2. Before You Give Clarithromycin 125mg/5ml Oral Suspension Do not give Clarithromycin 125mg/5ml Oral Suspension to your child: …

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Ciprofloxacin 250mg, 500mg, 750mg Tablets [Cipro, Ciproxin]

Generic Name: Ciprofloxacin Information For The User Ciprofloxacin 250mg Film-Coated Tablets Ciprofloxacin 500mg Film-Coated Tablets Ciprofloxacin 750mg Film-Coated Tablets 1. What Are Ciprofloxacin Tablets And What Are They Used For? Ciprofloxacin belongs to a group of medicines known as the quinolone antibacterials, fluoroquinolones. It has high anti-bacterial activity against a wide range of organisms. Ciprofloxacin works by killing bacteria that cause infections, it only works with specific strains of bacteria. Adults: Ciprofloxacin is used to treat the following bacterial infections: respiratory tract infections(Eg. certain types of pneumonia) long lasting or recurring ear or sinus infections urinary tract infections (bladder and kidneys infection) infections of the testicles genital organ infections in women(e.g. …

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Clarithromycin 250mg, 500mg Tablets [US: Biaxin]

Generic Name:¬†Clarithromycin Under what local brands and in what dosages is generic Fluconazole sold in pharmacies of Britain, United States, and Canada? In pharmacies of the United States, Great Britain and Canada the pharmacists offer you to buy Fluconazole according to your prescription or without a prescription under such brand names and in such strengths and dosage forms: UK US Canada Clarithromycin 250mg Tablets Clarithromycin 500mg Tablets Klaricid 250 mg Tablets Klaricid 500 mg Tablets Clarithromycin 250mg Tablets Clarithromycin 500mg Tablets Biaxin 250 mg Tablets Biaxin 500 mg Tablets Clarithromycin 250mg Tablets Clarithromycin 500mg Tablets Biaxin 250 mg Tablets Biaxin 500 mg Tablets Patient Information On Clarithromycin 250mg Film-coated Tablets Clarithromycin …

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