Antituberculosis drugs

Rimantadine Hydrochloride

C12H21N•HCl • Rimantadine hydrochloride is a synthetic antiviral agent that is structurally related to amantadine and active against influenza A virus. Uses • Influenza Virus Infection Rimantadine is used for the prophylaxis of infection caused by various human and animal strains of influenza A virus in adults and children and for the treatment of these infections in adults.While the optimum dose and duration of therapy have not been established, rimantadine also has been used for the treatment of influenza A virus infection in children. While chemoprophylaxis with the drug should not be considered a substitute for annual vaccination with influenza virus vaccine, antiviral agents are an important adjunct to influenza vaccine …

Continue Reading...

Dapsone

DDS • Dapsone, a synthetic sulfone, is an antimycobacterial and antiprotozoal agent. Cautions • Hematologic Effects The most frequent adverse effects of dapsone are dose-related hemolytic anemia and methemoglobinemia. Hemolysis occurs in most patients receiving 200 mg or more of dapsone daily; however, symptomatic anemia occurs only occasionally. The manufacturer states that the hemoglobin level is generally decreased by 1-2 g/dL, the reticulocyte count is increased 2-12%, erythrocyte life span is shortened, and methemoglobinemia occurs in most patients receiving dapsone. Heinz body formation also occurs frequently. Unless severe, hemolysis or methemoglobinemia does not generally require discontinuance of dapsone therapy. These adverse hematologic effects occur in patients with or without glucose-6-phosphate dehydrogenase …

Continue Reading...

Dapsone: Dosage and Administration

• Administration Dapsone is administered orally. For administration to children, commercially available tablets of dapsone have been crushed and dissolved in strawberry syrup; however, studies evaluating bioavailability of the drug following administration of this preparation have not been published to date. • Dosage Leprosy For the treatment of multibacillary leprosy, the World Health Organization (WHO) recommends that adults receive dapsone in a dosage of 100 mg daily in conjunction with rifampin (600 mg once monthly) and clofazimine (50 mg once daily and 300 mg once monthly) given for 12 months. Children 10-14 years of age with multibacillary leprosy should receive dapsone in a dosage of 50 mg daily in conjunction with …

Continue Reading...

Dapsone: Uses

• Leprosy Dapsone is used in rifampin-based multiple-drug regimens for the treatment of multibacillary and paucibacillary leprosy. Although dapsone was used alone in the past for the treatment of leprosy, the World Health Organization (WHO) and most clinicians currently recommend that rifampin-based multiple-drug regimens be used for the treatment of all forms of leprosy. Multiple-drug regimens may reduce infectiousness of the patient more rapidly as well as delay or prevent the emergence of resistant organisms. Rifampin-based regimens are necessary because of the increasing incidence of dapsone-resistant Mycobacterium leprae, and these regimens are designed to be effective against all strains of M. leprae, regardless of their susceptibility to dapsone. Because rifampin is …

Continue Reading...

Buy Lamprene (Clofazimine) Without Prescription 50mg

Clofazimine • Clofazimine is a phenazine dye with antimycobacterial and anti-inflammatory activity. Dosage and Administration • Administration Clofazimine is administered orally. Clofazimine should be taken with a meal to maximize absorption of the drug. • Dosage Clofazimine dosages exceeding 100 mg daily should be given for as short a period as possible and only under close medical supervision. Leprosy The usual adult dosage of clofazimine for the treatment of leprosy is 50-100 mg once daily. Clofazimine also is given in a dosage regimen that includes 50 mg once daily plus an additional 300-mg dose given once monthly. Multibacillary Leprosy For the treatment of multibacillary leprosy, the World Health Organization (WHO) and …

Continue Reading...

Buy Clofazimine (Lamprene) No Prescription 50mg

Clofazimine: Cautions Clofazimine generally is well tolerated when given in dosages of 100 mg daily or less. The major adverse effects of the drug involve the skin, eyes, and GI tract. Discoloration of various body tissues and fluids occurs in most patients receiving clofazimine, apparently because clofazimine is a bright-red dye and crystals of the drug are distributed to and accumulate in these tissues and fluids. Although most adverse effects of clofazimine are mild, dose related, and reversible following discontinuance of the drug, severe GI effects, which may be fatal, have been reported rarely. • Dermatologic Effects Pink to brownish-black discoloration of the skin occurs in up to 75-100% of patients …

Continue Reading...

Order Without Prescription Lamprene (Clofazimine) 50mg

Clofazimine: Uses • Leprosy Clofazimine is used in rifampin-based multiple-drug regimens for the treatment of multibacillary and paucibacillary leprosy. The drug also has been used in the treatment and prevention of erythema nodosum leprosum (ENL) reactions (lepra type 2 reactions) in leprosy patients. The World Health Organization (WHO) and most clinicians currently recommend that rifampin-based multiple-drug regimens be used for the treatment of all forms of leprosy. Multiple-drug regimens may reduce infectiousness of the patient more rapidly as well as delay or prevent the emergence of resistant organisms. Rifampin-based multiple-drug regimens are necessary because of the increasing incidence of dapsone-resistant Mycobacterium leprae, and these regimens are designed to be effective against …

Continue Reading...

Rifapentine

C47H64N4O12 • Rifapentine, a long-acting semisynthetic cyclopentylpiperazinyl derivative of rifamycin SV, is an ansamycin antituberculosis antibiotic. Dosage and Administration • Administration Rifapentine is administered orally. Since the incidence of some adverse effects (e.g., vomiting, nausea, or GI upset) may be increased during fasting conditions, administration of rifapentine with food may be useful in patients with a history of such disorders. GI absorption of rifapentine is reduced (e.g., by 20-32% in the fasted state) in HIV-infected patients compared with healthy adults, but concomitant administration with food can increase the extent of GI absorption of the drug. Rifapentine usually is given once or twice weekly, and the manufacturer recommends an interval of not …

Continue Reading...

Rifapentine: Uses

• Tuberculosis • Active Tuberculosis Rifapentine is used in conjunction with other antituberculosis agents in the treatment of clinical tuberculosis. The American Thoracic Society (ATS), US Centers for Disease Control and Prevention (CDC), and Infectious Diseases Society of America (IDSA) currently recommend several possible multiple-drug regimens for the treatment of culture-positive pulmonary tuberculosis. These regimens have a minimum duration of 6 months (26 weeks), and consist of an initial intensive phase (2 months) and a continuation phase (usually either 4 or 7 months). Rifapentine is considered a first-line antituberculosis agent for use in intermittent regimens in patients with pulmonary tuberculosis. Although the manufacturer states that rifapentine can be used in both …

Continue Reading...

Rifampin

• Rifampin is a rifamycin B-derivative antibiotic that is active against mycobacteria and some gram-positive and -negative bacteria. Drug Interactions • Antiretroviral Agents Rifamycin derivatives (e.g., rifampin, rifabutin) can accelerate the metabolism of certain antiretroviral agents (i.e., HIV protease inhibitors, nonnucleoside reverse transcriptase inhibitors [NNRTIs]) by induction of cytochrome P-450 (CYP) oxidases, which may result in subtherapeutic plasma concentrations of some of these protease inhibitors and NNRTIs. 194 Rifampin also can affect the pharmacokinetics of some nucleoside reverse transcriptase inhibitors (e.g., zidovudine). In addition, HIV protease inhibitors and some NNRTIs (e.g., delavirdine) reduce the metabolism of rifamycins, leading to increased plasma concentrations of rifamycins and an increased risk of toxicity. The …

Continue Reading...
CLOSE
CLOSE