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Clotrimazole [Lotrimin 15g]

(British Approved Name, US Adopted Name, rINN)

Drug Nomenclature

International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):

Synonyms: Bay-5097; Clotrimazol; Clotrimazolum; FB-5097; Klotrimatsoli; Klotrimazol; Klotrimazolas
INN: Clotrimazole [rINN (en)]
INN: Clotrimazol [rINN (es)]
INN: Clotrimazole [rINN (fr)]
INN: Clotrimazolum [rINN (la)]
INN: Клотримазол [rINN (ru)]
Chemical name: 1-(α-2-Chlorotrityl)imidazole
Molecular formula: C22H17ClN2 =344.8
CAS: 23593-75-1
ATC code: A01AB18; D01AC01; G01AF02
Read code: y00o9 [Ear]; y08EL [Skin]; y03Dg

Note. Compounded preparations of clotrimazole may be represented by the following names:

• Co-climasone (PEN)clotrimazole and betamethasone di-propionate.

Pharmacopoeias. In China, Europe, Japan, and US.


European Pharmacopoeia, 6th ed. (Clotrimazole). A white or pale yellow crystalline powder. Practically insoluble in water soluble in alcohol and in dichloromethane. Protect from light.

The United States Pharmacopeia 31, 2008 (Clotrimazole). A white to pale yellow, crystalline powder. Practically insoluble in water freely soluble in alcohol, in acetone, in chloroform, and in methyl alcohol. Store in airtight containers.

Adverse Effects and Precautions

Nausea, vomiting, unpleasant mouth sensations, and pruritus have been reported after the use of oral clotrimazole lozenges. Raised liver enzyme values have also occurred. Local reactions including irritation and a burning sensation may occur in patients treated topically contact allergic dermatitis has been reported. Intravaginal preparations of clotrimazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local application.

Gastrointestinal disturbance, elevation of liver enzymes, dysuria, and mental depression have been reported after oral clotrimazole (although this route is no longer used). For a discussion of the caution needed when using azole antifungals during pregnancy, see under Pregnancy in Precautions of Fluconazole.

Antimicrobial Action

Clotrimazole is an imidazole antifungal with antimicrobial activity similar to that of ketoconazole.


When applied topically clotrimazole penetrates the epidermis but there is little i † any systemic absorption. Absorption of 3 to 10% of a dose has been reported after vaginal use. Clotrimazole is metabolised in the liver to inactive compounds and excreted in the faeces and urine.

Uses and Administration

Clotrimazole is an imidazole antifungal used topically in superficial candidiasis, and in the skin infections pityriasis versicolor and dermatophytosis (see Skin Infections). Clotrimazole may also be used occasionally for symptomatic relie † of the protozoal infection trichomoniasis when other drugs are contra-indicated.

Clotrimazole is applied topically two or three times daily for 2 to 4 weeks as a 1% cream, lotion, spray, or solution in the treatment of fungal skin infections a 1% powder may be used with the cream or solution and has been applied to prevent re-infection. The 1% solution is also used topically for fungal otitis externa. Clotrimazole is given as pessaries in dosage regimens of 100 mg for 6 days, 200 mg for 3 days, or a single dose of 500 mg in the treatment of vulvovaginal candidiasis; similar doses are given as a 1, 2, or 10% vaginal cream. It may be necessary to treat balanitis in male partners concurrently.

For the treatment of oropharyngeal candidiasis one 10-mg lozenge of clotrimazole is dissolved in the mouth five times daily for 14 days. For the prophylaxis of oropharyngeal candidiasis in patients receiving immu-nosuppressant therapy the dose is one 10-mg lozenge three times daily for the duration of the immunosup-pressant treatment. Clotrimazole has also been given orally but has now been largely superseded by other azole drugs.

Sickle-cell disease. Oral clotrimazole has been investigated for the treatment of sickle-cell disease.


British Pharmacopoeia 2008: Clotrimazole Cream Clotrimazole Pessaries

The United States Pharmacopeia 31, 2008: Clotrimazole and Betamethasone Dipropionate Cream Clotrimazole Cream Clotrimazole Lotion Clotrimazole Lozenges Clotrimazole Topical Solution Clotrimazole Vaginal Tablets.

Proprietary Preparations

Argentina: Aflorix Clotri-Q Clotrix Empecid Eximius Ikolan Klomazole Livomonil Medifungol Micoclin Micomax Micomazol Micomazol Deo Mi-cosep Micosep B Micotrim Mycanden Panmicol Sinfung Trimazol

Australia: Canesten Chemists Own Clozole Clofeme Clonea Clotreme † Femizol Gyne-Lotrimin † Tinaderm Extra Topizol

Austria: Candibene Canesten Myko Cordes Pedikurol

Belgium: Canestene Gyno-Canestene †

Brazil: Antimicotico Martel Canesten Clomazen Clomazol Clotigen Clotren Clotriderm Clotrimix † Clotrizan Dermobene Gino-Canesten Gino-Clotrimix Kinasten Miclonazol Micosten † Micotrat Micotrizol † Neo Clotrimazyl

Canada: Canesten Clotrimaderm

Chile: Arnela Axasol Canesten Cestop † Clotrimin Cotrisan Creminem Funzal Gynocanesten Konifungil Laboterol † Novacetol Telugren

Czech Republic: Aknecolor Baycuten Candibene Canesten Canifug Imazol Jenamazol Plimycol †

Denmark: Canesten

Finland: Canesten

Germany: Antifungol Aru C † Azutrimazol † Benzoderm Mycof Candazol † Canesten Canifug Cloderm Clotrigalen cutistad † du-rafungol Fungiderm Fungizid Gilt Gyno-Canesten † Holfungin † Jenamazol † KadeFungin Mycofug Myko Cordes Mykofungin Mykohaug Ovis Neu † SD-Hermal Uromykol

Greece: Canesten Factodin

Hong Kong: Aristen Canesten Clocreme Clotri-Denk Clozole Cotren Fungizid † Gyne-Lotremin Kamicin Lotremin Mycoril Tricloderm Warimazol †

Hungary: Candibene Canesten Canifug

India: Candid Clocip Clozol Imidil Mycocid Mycoderm-C Surfaz

Indonesia: Bernesten Canesten Clonitia Fungiderm Gyne-Lotremin Kranos Lotremin Medisten Trimadan

Ireland: Canesten

Israel: Agisten Baby Agisten Clotrimaderm Myco-Hermal Oralten Troche

Italy: Antimicotico Canesten Gyno-Canesten

Malaysia: Candazole Candid Canesten Clomazole Cotren † Fungicip Gyne-Lotremin Gynostatum † Loriderm † Lotremin Micoter † Trimazol †

Mexico: Altenal Baycuten Candimon Candiphen Canesten Cinabel † Clocan Clomacin Dermasten Euroderm Liferzol Lomecan V Lonestin † Lotrimin Tenescan

The Netherlands: Canesten Parvemaxol

Norway: Canesten

New Zealand: Canesten Clocreme Clomazol Clotrihexal Clotrimaderm

Philippines: Candid V6 Canesten Cloxy Gixaderm Gynesol Vaf †

Poland: Canesten

Portugal: Candid † Canesten Diomicete Gino-Canesten Gino-Lotremine Lotremine Micolysin Nalbix Pan-Fungex

Russia: Amyclon † Antifungol Candibene Candid Candid V6 Canesten

South Africa: A-Por Canalba Candaspor Candizole Canesten Canex Closcript Covospor Fungispor Gyno-Trimaze † Medaspor Micomisan Mycoban † Mycohexal Normospor Stiemazol Trimaze Xeraspor

Singapore: Candazole Canesten Cotren Cristan Gyne-Lotremin † Lotremin † Myco-Hermal Mycoril Sastid Anti-Fungal Vanesten †

Spain: Canesten Fungidermo Gine Canesten

Sweden: Canesten

Switzerland: Acnecolor Canestene Corisol Eurosan † Fungotox Gromazol Gyno-Canestene Imazol Undex

Thailand: Caginal Canadine † Canazol Candazole Candid Candinox Canesten Chingazol Clotri † Clotricin Comat Cotren CST Defungo Dermaten Fango Cream Fungicon Fungiderm Gynebo Kanezin Klamacin Manomazole Mycoderm-C Mycozole Nestic Taraten Vamazole Vanesten Zema

Turkey: Canesten Clozol Fungosten Gyno-Canesten

UK: Abtrim † Candiden † Canesten Canesten Combi Fungederm Privacom †

USA: Gyne-Lotrimin Lotrimin Lotrimin A † Mycelex Mycelex-7

Venezuela: Canesten Clortilen Clotrizol Fugolin Ginolotricomb Gyno Canesten Imazol Ipalat Lecibis † Micozol Oxisol † Polik


Argentina: Becortin Calmurid Cortispec Dermovit † Empecid Cort Hongal Lotricomb Micomazol B Quaclriderm Quiacort G Plus Vagarne † Vagisan Compuesto Vitacortil

Australia: Canesoral Duo Hydrozole

Austria: Myko Cordes

Belgium: Lotriderm

Brazil: Baycuten

Canada: Lotriderm

Chile: B-Laboterol Baycuten Cestop B † Clotrimin-B Creminem-B Cutanil Donomix Locrim Lotriderm Novadrel Novarnela Telugren Plus Tribesona

Czech Republic: Imacort Imazol Plus Lotriderm †

Denmark: Clotrason

France: Triazol †

Germany: Antifungol Baycuten HC Baycuten † Canesten HC † Fungidexan Imazol Imazol comp Lotricomb Myko Cordes Plus

Hong Kong: Becogem Canesten HC Clobeta-G Clotrinolon Derzid-C Lozopin Synco-CFN Triderm

India: Candibiotic Candid B Candid Ear Drops Candid-TV Candiderma + Candiderma † Cloben-G Clocip B Clocip NB Clomycin Cutinorm † Fourderm A † NC-Derm Neocip FC Otek-AC+ Sigmaderm Sofradex † Surfaz Surfaz-SN Translipo-Triple

Indonesia: Baycuten-N Heltiskin Lotriderm

Ireland: Canesten HC Lotriderm

Israel: Agisten with Aloe Vera Clotrisone Hydroagisten Polycutan Tevacutan Triderm

Italy: Desamix Effe Meclon

Malaysia: Baycuten N Betamethasone Go Candacort Triderm-C

Mexico: Barmicil Compuesto Baycuten N Beclogen Betrigen Clotricina Gelmicin Miclobet Prubagen Quadriderm N † Triderm Xyloderm

New Zealand: Lotricomb †

Philippines: Baycuten Candibec Clotrasone Triderm

Poland: Lotriderm Triderm

Portugal: Baycuten Beta-Micoter Flotiran Quadriderme

Russia: Akriderm GK Candibiotic Candid B Metrogyl Plus Triderm

South Africa: Lotriderm

Singapore Candacort Canesten HC Clotrasone † Combiderm Gentriderm Gentrisone Modaderm Neoderm Triderm

Spain: Beta Micoter Clotrasone

Switzerland: Imacort Imazol Triderm

Thailand: Bacda-B Canasone † Canazol-BE Candacort Clotrasone † Derzid-C Fango-B Fungicon Fungiderm-B Gynesten-B Gynestin Mycla-B Myrazole-B Twina

Turkey: Imazol

UK: Canesten HC

USA: Lotrisone

Venezuela: Baycuten N Lotricomb Lotrisone Triderm.

The symbol † denotes a preparation no longer actively marketed.

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Spanish And French Translations Of Common Medication Words:

English Spanish French
Medications Medicamentos Médicaments
Tablets Comprimidos Comprimés
Capsules Cápsulas Gélules
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Synonyms of Clotrimazole *:

Chlotrimazole, Clotrimazol

* Official titles and synonyms used in the British, European, and US Pharmacopoeias. INNs in the other main official languages (French, Latin, and Spanish) have also been included in the list of synonyms where these differ from the English INN.

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Dosage forms of Clotrimazole:

Name, Strength, Form, Route
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Therapeutic classes of Clotrimazole:

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