Antifungal drugs

Buy Diflucan (Fluconazole) No Prescription 50/100/150/200mg

Fluconazole [US: Diflucan 50mg, 100mg, 150mg, 200mg] (British Approved Name, US Adopted Name, rINN) Drug Nomenclature Synonyms: Fluconazol; Fluconazolum; Flukonatsoli; Flukonazol; UK-49858 BAN: Fluconazole USAN: Fluconazole INN: Fluconazole [rINN (en)] INN: Fluconazol [rINN (es)] INN: Fluconazole [rINN (fr)] INN: Fluconazolum [rINN (la)] INN: Флуконазол [rINN (ru)] Chemical name: 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol Molecular formula: C13H12F2N6O =306.3 CAS: 86386-73-4 ATC code: D01AC15; J02AC01 Read code: y02Ug Pharmacopoeias. In China, Europe, and US. European Pharmacopoeia, 6th ed. (Fluconazole). A white or almost white, hygroscopic, crystalline powder. It exhibits polymorphism. Slightly soluble in water freely soluble in methyl alcohol soluble in acetone. Store in airtight containers. The United States Pharmacopeia 31, 2008, and Supplements 1 and 2 …

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Purchase Diflucan (Fluconazole) No Prescription 50/100/150/200mg

Fluconazole: Uses and Administration Fluconazole is a triazole antifungal used for superficial mucosal (oropharyngeal, oesophageal, or vaginal) candidiasis and for fungal skin infections. It is also given for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis, and has been tried in blastomycosis, histoplasmosis, and sporotrichosis. The place of fluconazole in the treatment of fungal infections is discussed in the various sections under Choice of Antifungal. Fluconazole is given by mouth or intravenous infusion in similar doses. For intravenous infusion it is given as a solution containing 2 mg/mL at a rate of 5 to 10 mL/minute (300 to 600 mL/hour). In the USA, a maximum infusion rate of 100 mL/hour is …

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Order Generic Fluconazole (Diflucan) No Prescription 50/100/150/200mg

Fluconazole: Interactions In general, fewer interactions are considered to occur with fluconazole than with either itraconazole or ketoconazole. Use of rifampicin with fluconazole results in reduced plasma concentrations of fluconazole. Use of hydrochlorothiazide and fluconazole has resulted in clinically insignificant increases in plasma-fluconazole concentrations. Fluconazole may interfere with the metabolism of some other drugs, mainly through inhibition of the cytochrome P450 isoenzymes CYP3A4 and CYP2C9. This may account for the reported increases in plasma concentrations of bosentan, ciclosporin, midazolam, nevirapine, amitriptyline, nortriptyline, phenytoin, rifabutin, sulfonylurea hypoglycaemics and nateglinide, selective cyclooxygenase-2-inhibitors such as celecoxib and parecoxib, tacrolimus, triazolam, warfarin, and zidovudine fluconazole may inhibit the formation of a toxic metabolite of sulfamethoxazole. …

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Antifungal Drugs – Targets of Antifungal Activity

Antifungal Drugs Antifungal drugs – targets of antifungal activity Itraconazole 100 mg Capsules Itraconazole is a triazole antifungal drug that is prescribed to patients with fungal infections, blastomycosis, histoplasmosis and onychomycosis. Itraconazole is also prescribed for systemic infections: aspergillosis, candidiasis and cryptococcosis where other antifungal drugs ineffective. Sporanox 100 mg Capsules Common brands (equivalents) of Itraconazole, which the pharmacists offer you to buy according to your prescription or without a prescription: Adco-Sporozole, Assosept-S, Bevonazole, Brovicton, Canadiol, Candistat, Canditral, Canifug Itra, Carexan, Cladostad, Conamed, Congox, Deratil, Derusil, Ergospharma, Etrel, Fitocyd, Flunol, Forcanox, Fulzoltec, Fungitrazol, Fungosin, Funit, Furolnok, Fuzoltec, Hongoseril, Idranox, Imazol, Iqcona, Isoflon, Isoporum, Isox, Itrabene, Itrabest, Itracan, Itracol, Itracon, Itraconal, Itralfa, …

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Antifungal Drugs

Fungal infections are particularly serious and common among neutropenic, immunocompromised patients who have received prolonged broad-spectrum antibiotics. A number of systemic fungal infections (e.g., histoplasmosis, coccidioidomycosis, and paracoccidioidomycosis) can also afflict otherwise healthy persons. Until recently, only amphotericin B was available to treat systemic fungal infection. However, with the rapid development and clinical assessment of azole compounds, a number of these agents are also considered appropriate for treatment of fungal infections. Amphotericin B is a polyene antibiotic that exerts its antifungal effect by binding to sterol moieties in the membranes of fungi. This causes pores in the cell wall, eventually causing leakage of low-molecular-weight cytoplasmic components. This effect, coupled with amphotericin’s …

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Flucytosine (Ancobon 250, 500mg)

5-FC • Flucytosine, a fluorinated pyrimidine analog, is a synthetic antifungal agent. Uses Oral flucytosine is used for the treatment of serious infections caused by susceptible strains of Candida or Cryptococcus neoformans and for the treatment of chromomycosis (chromoblastomycosis) caused by susceptible fungi. While flucytosine may be effective when used alone for the treatment of some fungal infections (e.g., candidal cystitis, chromomycosis), the drug should not be used alone in the treatment of severe, life-threatening infections. In the treatment of serious candidal or cryptococcal infections, flucytosine generally has been used as an adjunct to IV amphotericin B or an azole antifungal agent (e.g., fluconazole, itraconazole).Use of flucytosine in conjunction with amphotericin …

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Nystatin – Antifungal Drugs

• Nystatin is an antifungal antibiotic. Uses • Candidal Infections • Cutaneous and Mucocutaneous Candidal Infections Nystatin is used orally for the treatment of intestinal candidiasis. In patients with coexisting intestinal candidiasis and vulvovaginal candidiasis, nystatin has been administered orally in conjunction with intravaginal application of an antifungal agent. While early studies provided some limited evidence that, by reducing intestinal candidal colonization, combined oral and intravaginal antifungal therapy possibly could improve the mycologic response and reduce the recurrence rate of vulvovaginal candidiasis, most evidence suggests that combined therapy does not substantially reduce the risk of recurrence compared with intravaginal therapy alone. Nystatin has been administered orally as a suspension in conjunction …

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Amphotericin B (Fungilin, Fungizone, Abelcet, Fungisome, Amphocil)

• Amphotericin B, an amphoteric polyene macrolide, is an antifungal antibiotic. Drug Interactions Systematic drug interaction studies have not been performed to date using amphotericin B cholesteryl sulfate complex, amphotericin B lipid complex, or amphotericin B liposomal. The fact that drug interactions reported with conventional IV amphotericin B could also occur with these lipid-based or liposomal formulations of the drug should be considered. • Nephrotoxic Drugs Since nephrotoxic effects may be additive, the concurrent or sequential use of IV amphotericin B and other drugs with similar toxic potentials (e.g., aminoglycosides, capreomycin, colistin, cisplatin, cyclosporine, methoxyflurane, pentamidine, polymyxin B, vancomycin) should be avoided, if possible. Intensive monitoring of renal function is recommended …

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Amphotericin B: Cautions

Conventional IV amphotericin B is associated with a high incidence of adverse effects, and most patients who receive the drug experience potentially severe adverse effects at some time during the course of therapy. Acute infusion reactions (e.g., fever, chills, headache, nausea, vomiting) and nephrotoxicity are the most frequent adverse reactions to conventional IV amphotericin B. Although clinical experience with amphotericin B cholesteryl sulfate complex, amphotericin B lipid complex, and amphotericin B liposomal is limited to date, these drugs appear to be better tolerated than conventional IV amphotericin B. As with conventional IV amphotericin B, the most frequent adverse reactions to amphotericin B cholesteryl sulfate complex, amphotericin B lipid complex, or amphotericin …

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Amphotericin B: Dosage and Administration

• Reconstitution and Administration • Conventional Amphotericin B Conventional amphotericin B is administered by IV infusion. The drug also has been given intra-articularly, intrapleurally, intrathecally, or by local instillation or irrigation. For information regarding administration of the drug as an oral suspension and administration of the drug topically, subconjunctivally, or by local instillation or irrigation. Commercially available conventional amphotericin B for IV infusion must be reconstituted and diluted prior to administration. The drug must not be prepared with any diluents other than those specified below, and strict aseptic technique must be observed. Conventional amphotericin B should be reconstituted to a concentration of 5 mg/mL by adding 10 mL of sterile water …

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