Antibiotic Resistance

The major mdr efflux pump of Escherichia co//belongs to the RND superfamily and consists of the pump AcrB, the membrane fusion protein AcrA, and the porin TolC

The major mdr efflux pump of Escherichia co
The major mdr efflux pump of Escherichia co

The expression of the genes acrAB is under control of the local repressor AcrR, while tolC and acrAB are additionally regulated by several global transcriptional activators, like MarA induced by salicylate, SoxS derepressed by oxidants, and by Rob directly activated by bile salts.

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