Antibacterial drugs

Quinupristin and Dalfopristin

C53H67N9O10S • Quinupristin and dalfopristin is a combination of 2 semisynthetic streptogramin (synergistin) antibiotics that act synergistically against susceptible gram-positive bacteria. Uses • Vancomycin-resistant Enterococcus faecium Infections Quinupristin and dalfopristin is used IV in adults for the treatment of serious or life-threatening infections caused by susceptible strains of vancomycin-resistant Enterococcus faecium (VREF), including infections associated with VREF bacteremia. Quinupristin and dalfopristin became commercially available in the US for this indication under the principles and procedures of FDA’s accelerated review process that allows approval based on analysis of surrogate markers of response (i.e., clearance of bacteremia), rather than clinical end points such as cure of infection or survival.Controlled clinical studies are underway …

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Quinupristin and Dalfopristin: Dosage and Administration

• General • Reconstitution and Administration Quinupristin and dalfopristin is administered by IV infusion over 60 minutes. Quinupristin and dalfopristin powder for injection must be reconstituted and diluted prior to administration. The manufacturer states that only 5% dextrose injection or sterile water for injection should be used to reconstitute the powder, and further dilution should be with 5% dextrose. Strict aseptic technique must be observed since the drug contains no preservative. Vials labeled as containing 500 mg (150 mg of quinupristin and 350 mg of dalfopristin) should be reconstituted by slowly adding 5 mL of one of these diluents to provide a solution containing 100 mg/mL. The vial should be gently …

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Polymyxin B Sulfate

• Polymyxin B is a polymyxin antibiotic. Uses Systemic use of polymyxin B has, in most cases, been replaced by more effective and less toxic antibiotics for infections caused by susceptible organisms. However, polymyxin B may be useful in infections caused by organisms resistant to these drugs. Polymyxin B sulfate has been used in the treatment of acute infections of the urinary tract or meninges, and of septicemia caused by susceptible strains of Ps. aeruginosa. The drug has also been used in the treatment of meningeal infections caused by H. influenzae, urinary tract infections caused by E. coli, and bacteremia caused by E. aerogenes and K. pneumoniae. Polymyxin B sulfate is …

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Colistimethate Sodium

• Colistin (polymyxin E) is an antibiotic that is structurally and pharmacologically related to polymyxin B. Uses • Gram-negative Aerobic Bacterial Infections Colistimethate sodium is used in the treatment of acute or chronic infections caused by susceptible strains of certain gram-negative bacteria (e.g., Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa). Other more effective and less toxic anti-infectives (e.g., fluoroquinolones, aminoglycosides, third generation cephalosporins, extended-spectrum penicillins) usually are drugs of choice for most gram-negative bacterial infections, and colistimethate sodium should be used in the treatment of infections caused by susceptible gram-negative bacteria only when other more effective and less toxic anti-infectives are contraindicated or are ineffective. However, colistimethate sodium may be …

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Buy Linezolid (Zyvox) Without Prescription 600mg

Linezolid C16H20FN3O4 • Linezolid is a synthetic oxazolidinone anti-infective agent that is active against enterococci, staphylococci, and streptococci. Uses Linezolid is used orally and/or IV for the treatment of vancomycin-resistant Enterococcus faecium infections and for the treatment of community-acquired pneumonia, nosocomial pneumonia, and uncomplicated or complicated skin and skin structure infections caused by susceptible staphylococci or streptococci. Concomitant use of another anti-infective may be indicated in the treatment of some of these infections (e.g., nosocomial pneumonia, complicated skin and skin structure infections) if the documented or presumptive pathogens also include gram-negative bacteria. • Vancomycin-resistant Enterococcus faecium Infections Linezolid is used for the treatment of vancomycin-resistant E. faecium infections, including those associated …

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Lincomycin Hydrochloride

• Lincomycin is an antibiotic that is structurally related to clindamycin. Uses • Staphylococcal and Streptococcal Infections Lincomycin is used in the treatment of serious infections caused by susceptible strains of staphylococci, Streptococcus pneumoniae, and other streptococci; however, lincomycin is not considered the drug of choice in infections caused by gram-positive cocci and its use in these infections should be reserved for penicillin-allergic patients or other patients for whom less toxic alternatives (e.g., erythromycin) are contraindicated. Lincomycin should be not used for the treatment of minor bacterial infections or for nonbacterial infections. Because of poor CNS penetration, lincomycin should not be used in the treatment of meningitis. In general, lincomycin appears …

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Lincomycin Hydrochloride: Cautions

• GI Effects Adverse GI effects frequently occur with oral, IM, or IV lincomycin and may be severe enough to necessitate discontinuance of the drug. Adverse GI effects of lincomycin include nausea, vomiting, diarrhea, abdominal pain, tenesmus, glossitis, stomatitis, and pruritus ani. Nonspecific colitis and diarrhea, as well as potentially fatal Clostridium difficile-associated diarrhea and colitis (also known as antibiotic-associated pseudomembranous colitis), also have occurred in patients receiving lincomycin. Lincomycin-induced colitis usually is characterized by severe diarrhea and abdominal cramps and may be associated with the passage of blood or mucus; endoscopic examination is necessary to reveal the presence of pseudomembranes. Data from animal and clinical studies suggest that C. difficile-associated …

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Order Clindamycin (Cleocin) No Prescription 150/300mg

Clindamycin Hydrochloride, Clindamycin Palmitate Hydrochloride, Clindamycin Phosphate • Clindaymcin is a semisynthetic antibiotic that is a derivative of lincomycin. Spectrum Clindamycin is active against most aerobic gram-positive cocci including staphylococci, Streptococcus pneumoniae, and other streptococci (except Enterococcus faecalis [formerly S. faecalis]). The drug also is active in vitro against Arcanobacterium haemolyticum (formerly Corynebacterium haemolyticum). Clindamycin is active against some anaerobic and microaerophilic gram-negative and gram-positive organisms including Actinomyces, Bacteroides, Eubacterium, Fusobacterium, Propionibacterium, microaerophilic streptococci, Peptococcus, Peptostreptococcus, and Veillonella. Clindamycin is active in vitro against Prevotella and Porphyromonas (both formerly classified as Bacteroides); Mobiluncus (motile, anaerobic, curved rods) also are inhibited in vitro by the drug. Clostridium perfringens, C. tetani, Corynebacterium diphtheriae, …

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Buy Clindamycin (Cleocin) Without Prescription 150/300mg

Clindamycin Hydrochloride, Clindamycin Palmitate Hydrochloride, Clindamycin Phosphate: Cautions • GI Effects Adverse GI effects frequently occur with oral, IM, or IV clindamycin and may be severe enough to necessitate discontinuance of the drug. Adverse GI effects of clindamycin include nausea, vomiting, diarrhea, abdominal pain, and tenesmus. In addition, flatulence, bloating, anorexia, weight loss, and esophagitis have occurred. An unpleasant or metallic taste has occurred occasionally following IV administration of high doses of the drug. Nonspecific colitis and diarrhea, as well as potentially fatal Clostridium difficile-associated diarrhea and colitis (also known as antibiotic-associated pseudomembranous colitis), have also occurred in patients receiving clindamycin. • Diarrhea and Colitis C. difficile-associated diarrhea and colitis induced …

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Order Cleocin (Clindamycin) No Prescription 150/300mg

Clindamycin Hydrochloride, Clindamycin Palmitate Hydrochloride, Clindamycin Phosphate: Dosage and Administration • Reconstitution and Administration Clindamycin hydrochloride and clindamycin palmitate hydrochloride are administered orally. Clindamycin phosphate is administered by IM injection or by intermittent or continuous IV infusion. • Oral Administration Clindamycin hydrochloride capsules and clindamycin palmitate hydrochloride oral solution can be administered without regard to food. To avoid the possibility of esophageal irritation, clindamycin hydrochloride capsules should be administered orally with a full glass of water. Clindamycin palmitate hydrochloride oral solution is reconstituted by adding 75 mL of water to the 100-mL bottle; a large portion of the 75 mL should be added initially and the bottle shaken vigorously, and then …

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