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[ Continue Reading... ]Clarithromycin: Drug-Drug Interactions Antifungal imidazoles In three patients with pulmonary MAC and aspergillosis infections, itraconazole was suggested to increase the plasma concentration of clarithromycin as well as the clarithromycin:14-hydroxyclarithromycin ratio. This effect may have been due to inhibition of CYP3A4 by itraconazole. Antihistamines Toxic effects of terfenadine and astemizole have been reported in patients taking concomitant macrolides, especially clarithromycin, typically resulting in prolongation of the QT interval and cardiac dysrhythmias (torsade de pointes). Cisapride Cisapride can prolong the QT interval, with a risk of ventricular dysrhythmias. Clarithromycin increases …
[ Continue Reading... ]Fluconazole: Drug-Drug Interactions Alfentanil In a randomized, double-blind, placebo-controlled, crossover study in nine subjects, fluconazole 400 mg reduced the clearance of alfentanil 20 micrograms/kg by 55% and increased alfentanil-induced subjective effects. Amitriptyline An interaction of fluconazole with amitriptyline has been reported. • A 12-year-old boy with prostatic rhabdomyosarcoma had episodes of syncope periodically over 7 months while taking fluconazole for chemotherapy-induced mucositis. He had taken fluconazole in the past without problems but had also taken a stable dose of amitriptyline for neuropathic pain. On withdrawal of amitriptyline he had no further episodes. …
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Therapeutic classes of Zidovudine:
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Dosage forms of Zidovudine:
| Form | Route | Strength |
|---|---|---|
| Capsule | Oral | |
| Liquid | Intravenous | |
| Syrup | Oral |
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