Generic Name: Clarithromycin Information For The User 1. What Clarithromycin 125mg/5ml Oral Suspension Is And What It Is Used For Clarithromycin 125mg/5ml oral suspension contains clarithromycin. Clarithromycin belongs to a group of antibiotics called macrolides. Clarithromycin works by destroying some types of bacteria that cause certain infections. Clarithromycin may be used to treat infections that are …
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[ Continue Reading... ]Since the days when chloramphenicol was more commonly used, it has been recognized that many antimicrobial drug are associated with severe blood dyscrasias, such as aplastic anemia, neutropenia, agranulocytosis, throm-bocytopenia, and hemolytic anemia. Information on this association has come predominantly from case series and hospital surveys (38^. Some evidence can be extracted from population-based studies that have focused on aplastic anemia and agranulocytosis and their association with many drugs, including antimicrobial drugs. The incidence rates of blood dyscrasias in the general population have been estimated in a cohort study with a nested case-control analysis, using data from a General …
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[ Continue Reading... ]Clarithromycin: Organs and Systems Cardiovascular • QT interval prolongation and a ventricular dysrhythmia occurred in an HIV-positive 30-year-old man at the start of intravenous clarithromycin therapy 500 mg 12-hourly. Intravenous clarithromycin caused thrombophlebitis in four patients when it was given inappropriately as a rapid bolus injection instead of a short infusion; the manufacturers have received other reports of similar reactions, even with infusions, but the incidence seems to be considerably lower than with erythromycin. In a prospective, non-randomized study, phlebitis occurred in 15 of 19 patients treated with intravenous erythromycin (incidence rate of …
[ Continue Reading... ]Moxifloxacin: Organs and Systems Cardiovascular Moxifloxacin blocks the rapid-component delayed-rectifier potassium channel in the heart, and thus prolongs the QTC interval by 6 minutes after oral administration and 12 minutes after intravenous administration. Moxifloxacin carries a greater risk of QT interval prolongation than ciprofloxacin, levofloxacin, and ofloxacin, and although the risk of moxifloxacin-induced tor-sade de pointes is expected to be minimal when the drug is given in the recommended dosage (400 mg/day), moxifloxacin should be used with caution in patients with prodysrhythmic conditions and avoided in patients taking antidysrhythmic drugs, such as quinidine, procainamide, amiodarone, …
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