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Chloroquine is authorised in the world under the following brand names: 3377 RP opalate, Amokin, Aralen, Aralen HCl, Arechin, Arthrochin, Artrichin, Avlochlor, Avloclor, Bemaco, Bemaphate, Bemasulph, Benaquin, Bipiquin, Capquin, Chemochin, Chingamin, Chlorochin, Cidanchin, Cocartrit, Delagil, Dichinalex, Elestol, Gontochin, Heliopar, Imagon, Iroquine, Klorokin, Lapaquin, Malaquin, Malaren, Malarex, Mesylith, Neochin, Nivachine, Nivaquine, Nivaquine B, Pfizerquine, Plaquenil, Quinachlor, Quinagamin, Quinagamine, Quinercyl, Quingamine, Quinilon, Quinoscan, Resochen, Resochin, Resoquina, Resoquine, Reumachlor, Reumaquin, Roquine, Sanoquin, Silbesan, Siragan, Solprina, Sopaquin, Tanakan, Tresochin, Trochin.
Chloroquine and Hydroxychloroquine: Organs and Systems. Skin
Skin lesions and eruptions of different types have been attributed to chloroquine, including occasional cases of epidermal necrolysis.
The most common dermatological adverse event associated with chloroquine is skin discomfort (often called pruritus). It is much more common in people with darker skins and has been ascribed to chloroquine binding to increased melanin concentrations in the skin. In a pharmacokinetic study, the ratio of AUCo-48 for chloroquine and its major metabolite desethylchloroquine was significantly higher in the plasma and urine of 18 patients with chloroquine-induced pruritus than in that of 18 patients without. These results imply that differences in metabolism and higher chloroquine concentrations may be partly responsible for chloroquine-induced pruritus.
Pruritus begins about 10 hours after the start of treatment, with a maximum intensity at about 24 hours. These times correspond to maximum serum concentrations of chloroquine and its metabolites after oral ingestion. In many cases, the itch is confined to the palms of the hands and the soles of the feet. In a study in Nigeria, the incidence of pruritus was 60-75%; the itch was considered unbearable in 40%, and 30% refused further chloroquine. In a second study, there was an even higher incidence. In a study elsewhere, the incidence of pruritus was 27%. Not surprisingly, pruritus is a major cause of non-adherence to treatment, and it may contribute largely to the emergence and spread of resistant P. falciparum. Pruritus is more often seen in black-skinned than in white-skinned people in Africa, a difference that has been ascribed to the binding of chloroquine to melanin, and hence a racial predisposition. No such reports have come from America. Antihistamine treatment can have a preventive effect on pruritus. Other treatments that have been mentioned include prednisone and niacin, but the results were not impressive.
A few cases of psoriasis, or severe exacerbation of psoriasis shortly after the start of treatment, have been reported.
Photosensitivity and photo-allergic dermatitis have been seen, particularly during prolonged therapy with high doses.
Blue-black pigmentation involving the palate and facial, pretibial, and subungual areas occurs rarely, but it has been associated with retinopathy. The nail bed can turn blue-brown and the nail itself may develop longitudinal stripes and show a blue-grey fluorescence.
Chloroquine can cause vitiligo.
Fatal toxic epidermal necrolysis has been associated with hydroxychloroquine.
• A 39-year-old woman with rheumatoid arthritis took hydroxychloroquine 200 mg bd for painful synovitis, in addition to meloxicam, co-dydramol, and Gaviscon. She inadvertently took twice the prescribed dose of hydroxychloroquine, but stopped it after 2 weeks because of nausea. The next day she developed a widespread blotchy erythema and 2 weeks later was admitted to hospital with clinical and histological toxic epidermal necrolysis and deteriorated rapidly with multiorgan failure; she died 1 week later.
There have been only a few isolated reports of Stevens-Johnson syndrome associated with hydroxychloroquine. Recently, a clear temporal relation to the start of treatment with hydroxychloroquine has been documented in a patient with rheumatoid arthritis.
An increased frequency of skin reactions to hydroxychloroquine was noted in 11 patients (seven of whom had systemic lupus erythematosus, two discoid lupus, and two a lupus-like syndrome) when a coloring agent (sunshine yellow E was removed from the formulation; the authors were unable to explain this unexpected finding.
There have been four case reports of photosensitivity associated with hydroxychloroquine which has an estimated incidence of about 10 per 1000 patient-years.
Hydroxychloroquine causes skin reactions such as urticaria. There is some support for the contention that hydroxychloroquine causes skin reactions more often than chloroquine.
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Spanish And French Translations Of Common Medication Words:
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Synonyms of Chloroquine *:
Chloraquine, Chlorochine, Chloroquina, Chloroquine Phosphate, Chloroquinium, Chlorquin, Clorochina, Hydroxychloroquine Sulfate
* Official titles and synonyms used in the British, European, and US Pharmacopoeias. INNs in the other main official languages (French, Latin, and Spanish) have also been included in the list of synonyms where these differ from the English INN.
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Dosage forms of Chloroquine:
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|Chloroquine Tablet Oral|
Therapeutic classes of Chloroquine:
Amebicides, Antimalarials, Antirheumatic Agents
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