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(British Approved Name, US Adopted Name, rINN)
Drug Nomenclature
Read indications for use if you want to order Lincomycin online
International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish):
Lincomycin Hydrochloride
Drug Nomenclature
Pharmacopoeias. In China, Europe, Japan, US, and Vietnam.
European Pharmacopoeia, 6th ed., 2008 and Supplements 6.1 and 6.2 (Lincomycin Hydrochloride). An antimicrobial substance produced by Streptomyces lincolnensis var. lincolnensis or by any other means. A white or almost white crystalline powder. It contains not more than 5% of lincomycin B. Very soluble in water; slightly soluble in alcohol; very slightly soluble in acetone. A 10% solution in water has a pH of 3.5 to 5.5. Store at a temperature not exceeding 30° in airtight containers.
The United States Pharmacopeia 31, 2008 (Lincomycin Hydrochlonde). A white or practically white crystalline powder, odourless or with a faint odour. Freely soluble in water; very slightly soluble in acetone; soluble in dimethylformamide. pH of a 10% solution in water is between 3.0 and 5.5. Store in airtight containers.
Incompatibility. Solutions of lincomycin hydrochloride have an acid pH and incompatibility may be expected with alkaline preparations, or with drugs unstable at low pH.
Adverse Effects, Treatment, and Precautions
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As for Clindamycin.
Hyper sensitivity reactions such as skin rashes, urticaria, and angioedema may be less frequent with lincomycin than with clindamycin. Other adverse effects reported rarely with lincomycin include aplastic anaemia, pancytopenia, tinnitus, and vertigo. Lincomycin should be used with caution in patients with hepatic or renal impairment; consideration should be given to decreasing the dosage frequency and serum concentrations should be monitored during high-dose therapy. Reduced doses may be necessary in those with severe renal impairment (see below).
Interactions
When you buy cheap Lincomycin you must know how to use it
As for Clindamycin.
Absorption of lincomycin is reduced by adsorbent antidiarrhoeals and cyclamate sweeteners.
Antimicrobial Action
As for Clindamycin, but it is less potent. There is complete cross-resistance between clindamycin and lincomycin. Some cross-resistance with erythromycin, including a phenomenon known as dissociated cross-resistance or macrolide effect, has been reported.
Pharmacokinetics
About 20 to 30% of an oral dose of lincomycin is rapidly absorbed from the gastrointestinal tract; after a 500-mg dose, peak plasma concentrations of about 2 to 3 micrograms/mL are reached within 2 to 4 hours. Food markedly reduces the rate and extent of absorption. An intramuscular injection of 600 mg produces average peak plasma concentrations of between 11 and 12 micrograms/mL at 60 minutes and a 2-hour intravenous infusion of 600 mg produces an average of about 16 micrograms/mL.
The biological half-life of lincomycin is about 5 hours and may be prolonged in hepatic or renal impairment. Serum half-life maybe doubled in patients with hepatic impairment and up to 3 times longer in those with severe renal impairment. Lincomycin is widely distributed in the tissues including bone and body fluids but diffusion into the CSF is poor, although it may be slightly better when the meninges are inflamed. It diffuses across the placenta and is distributed into breast milk.
Lincomycin is partially inactivated in the liver; unchanged drug and metabolites are excreted in the urine, bile, and faeces. Lincomycin is not effectively removed from the blood by haemodialysis or peritoneal dialysis.
Uses and Administration
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Lincomycin is a lincosamide antibacterial with actions and uses similar to those of its chlorinated derivative, clindamycin. Clindamycin is usually preferred to lincomycin because of its greater activity and better absorption, although the usefulness of both drugs is limited by the risk of pseudomembranous colitis. Lincomycin is given orally or parenterally as the hydrochloride but doses are expressed in terms of the base; 1.13 g of lincomycin hydrochloride is equivalent to about 1 g of lincomycin. The usual adult oral dose is 500 mg 3 or 4 times daily, taken at least 1 or 2 hours before or after food. It is given parenterally by intramuscular injection in a dose of 600 mg once or twice daily, or by slow intravenous infusion in a dose of 0.6 to 1 g two or three times daily. Higher intravenous doses have been given in very severe infections, up to a total daily dose of about 8 g. For intravenous use, lincomycin 1 g should be diluted in not less than 100 mL of diluent and infused over at least 1 hour. For details of reduced doses in renal impairment, see below.
For details of doses in infants and children, see below. Lincomycin hydrochloride may be given by subconjunctival injection in a dose equivalent to 75 mg of lincomycin.
Administration in children. The usual oral dose of lincomycin for infants and children aged 1 month and over is 30 to 60 mg/kg daily in divided doses. It is given parenterally to those over 1 month old in a dose of 10 to 20 mg/kg daily in divided doses by intramuscular injection or intravenous infusion. For suggested doses in children with renal impairment see below.
Administration in renal impairment. Doses of lincomycin may need to be reduced in patients with severe renal impairment; a reduction down to 25 to 30% of the usual dose (see above) may be appropriate.
Preparations
British Pharmacopoeia 2008: Lincorrycin Capsules; Lincomycin Injection;
The United States Pharmacopeia 31, 2008: Lincomycin Hydrochloride Capsules; Lincomycin Hydrochloride Syrup; Lincomycin Injection.
Proprietary Preparations
Argentina: Frademicina;
Australia: Lincocin;
Belgium: Lincocin;
Brazil: Frademicina; Framicin †; Linatron; Lincoflan; Lincomiral; Lincomyn †; Lincoplax †; Lincotax †; Lincovax; Lindemicina; Neo Linco;
Canada: Lincocin;
Chile: Lincocin;
Czech Republic: Lincocin †; Neloren;
France: Lincocine;
Germany; Albiotic †;
Greece: Lincocin; Pecasolin;
Hong Kong; Lincocin; Medoglycin †;
India: Lynx;
Indonesia: Biolincom; Ethilin; Linco; Lincocin; Lincophar; Lincyn; Lintropsin; Nichomycin; Percocyn; Pritalinc; Tamcocin; Tismamisin; Zumalin;
Italy: Lincocin;
Malaysia: Linco; Lincosa; Medoglycin †;
Mexico: Libiocid; Limidrax; Linbac; Lincocin; Lincopat; Lincover; Lisonin; Princol; Rimsalin; Yectolin;
Philippines: Adlynx; Lincocin;
Poland: Lincocin; Neloren;
Portugal: Lincocina;
Russia: Neloren;
South Africa; Lincocin;
Singapore: Lincocin;
Spain: Cillimicina; Lincocin;
Thailand: Linco; Lincocilin; Lincocin; Lincogin †; Lincolan; Lincomax; Lincomy †; Lincono; Lingo; Linmycin; Utolincomycin;
Turkey: Lincocin; Lincomed; Linkoles; Linkosol; Linosin;
US (USA): Lincocin; Lincorex †;
Venezuela: Bekalen †; Formicina; Lincocin.
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Spanish And French Translations Of Common Medication Words:
| English | Spanish | French |
|---|---|---|
| Medications | Medicamentos | Médicaments |
| Tablets | Comprimidos | Comprimés |
| Capsules | Cápsulas | Gélules |
Pharmacies in the United States
Top 10 Pharmacy chains in the U. S. ranked by the number of pharmacists:| 1 Walgreens | 2 CVS | 3 Walmart | 4 Rite Aid | 5 Kroger |
| 6 Target | 7 Kaiser Permanente | 8 Sears | 9 Cardinal Health | 10 Dominick's |
Pharmacy-led chains in the United Kingdom
| Alliance Boots | The Co-operative | Lloyds Pharmacy |
| Numark | Rowlands Pharmacy | Superdrug |
Synonyms of Clindamycin *:
Clindamicina [INN-Spanish], clindamycin, Clindamycin Hcl, Clindamycin Hydrochloride, Clindamycin Phosphate, Clindamycine [French], Clindamycine [INN-French], Clindamycinum [INN-Latin]
* Official titles and synonyms used in the British, European, and US Pharmacopoeias. INNs in the other main official languages (French, Latin, and Spanish) have also been included in the list of synonyms where these differ from the English INN.
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Dosage forms of Clindamycin:
| Name, Strength, Form, Route |
|---|
| Clindamycin Capsule Oral |
| Clindamycin Cream Intravaginal |
| Clindamycin Cream Topical |
| Clindamycin Liquid Intramuscular |
| Clindamycin Liquid Intravenous |
| Clindamycin Powder, for solution Oral |
| Clindamycin Solution Intravenous |
| Clindamycin Solution Topical |
Therapeutic classes of Clindamycin:
Anti-Bacterial Agents, Lincomycins, Protein Synthesis Inhibitors
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