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Itraconazole is authorised in the world under the following brand names: Hyphanox, Itrizole, Oriconazole, Sporal, Sporanos, Sporanox, Sporonox, Triasporn.
- Drug Nomenclature
- Adverse Effects and Precautions
- Antimicrobial Action
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(British Approved Name, US Adopted Name, rINN)
Pharmacopoeias. In Japan, Poland, and US.
The United States Pharmacopeia 31, 2008 (Natamycin). An off-white to cream-coloured powder. It may contain up to 3 moles of water. Practically insoluble in water soluble in glacial acetic acid and in dimethylformamide slightly soluble in methyl alcohol. A 1 % suspension in water has apH of 5.0 to 7.5. Store in airtight containers. Protect from light.
Adverse Effects and Precautions
Gastrointestinal disturbances have occurred after oral use of natamycin. Local application has sometimes produced irritation.
Porphyria. Natamycin has been associated with acute attacks of porphyria and is considered unsafe in porphyric patients.
Natamycin is a polyene antifungal active against Candida and Fusarium spp. In addition it is active against the protozoan Trichomonas vaginalis.
Natamycin is poorly absorbed from the gastrointestinal tract. It is not absorbed through the skin or mucous membranes when applied topically. After ocular use, natamycin is present in therapeutic concentrations in corneal stroma but not in intra-ocular fluid systemic absorption does not usually occur.
Uses and Administration
Natamycin is a polyene antifungal antibiotic produced by the growth of Streptomyces natalensis. It is used for the local treatment of candidiasis and fungal keratitis (see Eye Infections). It has also been used in vaginal trichomoniasis.
Natamycin lozenges are used for the treatment of oral candidiasis in a dose of 10 mg every 4 to 6 hours. Tablets have been given orally for the treatment of intestinal candidiasis. Natamycin has also been used topically for fungal skin infections and for candi-dal and trichomonal infections of the vagina.
The United States Pharmacopeia 31, 2008: Natamycin Ophthalmic Suspension.
Czech Republic: Pimatucin
Germany: Deronga Heilpaste † Pima Biciron N Pimatucin
Italy: Natafucin †
The Netherlands: Pimatucin
Russia: Piamtucin † Pimatucin
South Africa: Natacyn
Czech Republic: Pimafucort
New Zealand: Pimafucort
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Itraconazole is a triazole antifungal drug that is prescribed to patients with fungal infections, blastomycosis, histoplasmosis and onychomycosis. Itraconazole is also prescribed for systemic infections: aspergillosis, candidiasis and cryptococcosis where other antifungal drugs ineffective.
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Spanish And French Translations Of Common Medication Words:
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Synonyms of Itraconazole *:
ITC, ITCZ, ITR, Itraconazol [Spanish], itraconazole, Itraconazolum [Latin], ITZ
* Official titles and synonyms used in the British, European, and US Pharmacopoeias. INNs in the other main official languages (French, Latin, and Spanish) have also been included in the list of synonyms where these differ from the English INN.
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Dosage forms of Itraconazole:
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Therapeutic classes of Itraconazole:
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