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Clotrimazole [Lotrimin 15g]
(British Approved Name, US Adopted Name, rINN)
Drug Nomenclature
International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):
Note. Compounded preparations of clotrimazole may be represented by the following names:
• Co-climasone (PEN) — clotrimazole and betamethasone di-propionate.
Pharmacopoeias. In China, Europe, Japan, and US.
European Pharmacopoeia, 6th ed. (Clotrimazole). A white or pale yellow crystalline powder. Practically insoluble in water soluble in alcohol and in dichloromethane. Protect from light.
The United States Pharmacopeia 31, 2008 (Clotrimazole). A white to pale yellow, crystalline powder. Practically insoluble in water freely soluble in alcohol, in acetone, in chloroform, and in methyl alcohol. Store in airtight containers.
Adverse Effects and Precautions
Nausea, vomiting, unpleasant mouth sensations, and pruritus have been reported after the use of oral clotrimazole lozenges. Raised liver enzyme values have also occurred. Local reactions including irritation and a burning sensation may occur in patients treated topically contact allergic dermatitis has been reported. Intravaginal preparations of clotrimazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local application.
Gastrointestinal disturbance, elevation of liver enzymes, dysuria, and mental depression have been reported after oral clotrimazole (although this route is no longer used). For a discussion of the caution needed when using azole antifungals during pregnancy, see under Pregnancy in Precautions of Fluconazole.
Antimicrobial Action
Clotrimazole is an imidazole antifungal with antimicrobial activity similar to that of ketoconazole.
Pharmacokinetics
When applied topically clotrimazole penetrates the epidermis but there is little i † any systemic absorption. Absorption of 3 to 10% of a dose has been reported after vaginal use. Clotrimazole is metabolised in the liver to inactive compounds and excreted in the faeces and urine.
Uses and Administration
Clotrimazole is an imidazole antifungal used topically in superficial candidiasis, and in the skin infections pityriasis versicolor and dermatophytosis (see Skin Infections). Clotrimazole may also be used occasionally for symptomatic relie † of the protozoal infection trichomoniasis when other drugs are contra-indicated.
Clotrimazole is applied topically two or three times daily for 2 to 4 weeks as a 1% cream, lotion, spray, or solution in the treatment of fungal skin infections a 1% powder may be used with the cream or solution and has been applied to prevent re-infection. The 1% solution is also used topically for fungal otitis externa. Clotrimazole is given as pessaries in dosage regimens of 100 mg for 6 days, 200 mg for 3 days, or a single dose of 500 mg in the treatment of vulvovaginal candidiasis; similar doses are given as a 1, 2, or 10% vaginal cream. It may be necessary to treat balanitis in male partners concurrently.
For the treatment of oropharyngeal candidiasis one 10-mg lozenge of clotrimazole is dissolved in the mouth five times daily for 14 days. For the prophylaxis of oropharyngeal candidiasis in patients receiving immu-nosuppressant therapy the dose is one 10-mg lozenge three times daily for the duration of the immunosup-pressant treatment. Clotrimazole has also been given orally but has now been largely superseded by other azole drugs.
Sickle-cell disease. Oral clotrimazole has been investigated for the treatment of sickle-cell disease.
Preparations
British Pharmacopoeia 2008: Clotrimazole Cream Clotrimazole Pessaries
The United States Pharmacopeia 31, 2008: Clotrimazole and Betamethasone Dipropionate Cream Clotrimazole Cream Clotrimazole Lotion Clotrimazole Lozenges Clotrimazole Topical Solution Clotrimazole Vaginal Tablets.
Proprietary Preparations
Argentina: Aflorix Clotri-Q Clotrix Empecid Eximius Ikolan Klomazole Livomonil Medifungol Micoclin Micomax Micomazol Micomazol Deo Mi-cosep Micosep B Micotrim Mycanden Panmicol Sinfung Trimazol
Australia: Canesten Chemists Own Clozole Clofeme Clonea Clotreme † Femizol Gyne-Lotrimin † Tinaderm Extra Topizol
Austria: Candibene Canesten Myko Cordes Pedikurol
Belgium: Canestene Gyno-Canestene †
Brazil: Antimicotico Martel Canesten Clomazen Clomazol Clotigen Clotren Clotriderm Clotrimix † Clotrizan Dermobene Gino-Canesten Gino-Clotrimix Kinasten Miclonazol Micosten † Micotrat Micotrizol † Neo Clotrimazyl
Canada: Canesten Clotrimaderm
Chile: Arnela Axasol Canesten Cestop † Clotrimin Cotrisan Creminem Funzal Gynocanesten Konifungil Laboterol † Novacetol Telugren
Czech Republic: Aknecolor Baycuten Candibene Canesten Canifug Imazol Jenamazol Plimycol †
Denmark: Canesten
Finland: Canesten
Germany: Antifungol Aru C † Azutrimazol † Benzoderm Mycof Candazol † Canesten Canifug Cloderm Clotrigalen cutistad † du-rafungol Fungiderm Fungizid Gilt Gyno-Canesten † Holfungin † Jenamazol † KadeFungin Mycofug Myko Cordes Mykofungin Mykohaug Ovis Neu † SD-Hermal Uromykol
Greece: Canesten Factodin
Hong Kong: Aristen Canesten Clocreme Clotri-Denk Clozole Cotren Fungizid † Gyne-Lotremin Kamicin Lotremin Mycoril Tricloderm Warimazol †
Hungary: Candibene Canesten Canifug
India: Candid Clocip Clozol Imidil Mycocid Mycoderm-C Surfaz
Indonesia: Bernesten Canesten Clonitia Fungiderm Gyne-Lotremin Kranos Lotremin Medisten Trimadan
Ireland: Canesten
Israel: Agisten Baby Agisten Clotrimaderm Myco-Hermal Oralten Troche
Italy: Antimicotico Canesten Gyno-Canesten
Malaysia: Candazole Candid Canesten Clomazole Cotren † Fungicip Gyne-Lotremin Gynostatum † Loriderm † Lotremin Micoter † Trimazol †
Mexico: Altenal Baycuten Candimon Candiphen Canesten Cinabel † Clocan Clomacin Dermasten Euroderm Liferzol Lomecan V Lonestin † Lotrimin Tenescan
The Netherlands: Canesten Parvemaxol
Norway: Canesten
New Zealand: Canesten Clocreme Clomazol Clotrihexal Clotrimaderm
Philippines: Candid V6 Canesten Cloxy Gixaderm Gynesol Vaf †
Poland: Canesten
Portugal: Candid † Canesten Diomicete Gino-Canesten Gino-Lotremine Lotremine Micolysin Nalbix Pan-Fungex
Russia: Amyclon † Antifungol Candibene Candid Candid V6 Canesten
South Africa: A-Por Canalba Candaspor Candizole Canesten Canex Closcript Covospor Fungispor Gyno-Trimaze † Medaspor Micomisan Mycoban † Mycohexal Normospor Stiemazol Trimaze Xeraspor
Singapore: Candazole Canesten Cotren Cristan Gyne-Lotremin † Lotremin † Myco-Hermal Mycoril Sastid Anti-Fungal Vanesten †
Spain: Canesten Fungidermo Gine Canesten
Sweden: Canesten
Switzerland: Acnecolor Canestene Corisol Eurosan † Fungotox Gromazol Gyno-Canestene Imazol Undex
Thailand: Caginal Canadine † Canazol Candazole Candid Candinox Canesten Chingazol Clotri † Clotricin Comat Cotren CST Defungo Dermaten Fango Cream Fungicon Fungiderm Gynebo Kanezin Klamacin Manomazole Mycoderm-C Mycozole Nestic Taraten Vamazole Vanesten Zema
Turkey: Canesten Clozol Fungosten Gyno-Canesten
UK: Abtrim † Candiden † Canesten Canesten Combi Fungederm Privacom †
USA: Gyne-Lotrimin Lotrimin Lotrimin A † Mycelex Mycelex-7
Venezuela: Canesten Clortilen Clotrizol Fugolin Ginolotricomb Gyno Canesten Imazol Ipalat Lecibis † Micozol Oxisol † Polik
Multi-ingredient
Argentina: Becortin Calmurid Cortispec Dermovit † Empecid Cort Hongal Lotricomb Micomazol B Quaclriderm Quiacort G Plus Vagarne † Vagisan Compuesto Vitacortil
Australia: Canesoral Duo Hydrozole
Austria: Myko Cordes
Belgium: Lotriderm
Brazil: Baycuten
Canada: Lotriderm
Chile: B-Laboterol Baycuten Cestop B † Clotrimin-B Creminem-B Cutanil Donomix Locrim Lotriderm Novadrel Novarnela Telugren Plus Tribesona
Czech Republic: Imacort Imazol Plus Lotriderm †
Denmark: Clotrason
France: Triazol †
Germany: Antifungol Baycuten HC Baycuten † Canesten HC † Fungidexan Imazol Imazol comp Lotricomb Myko Cordes Plus
Hong Kong: Becogem Canesten HC Clobeta-G Clotrinolon Derzid-C Lozopin Synco-CFN Triderm
India: Candibiotic Candid B Candid Ear Drops Candid-TV Candiderma + Candiderma † Cloben-G Clocip B Clocip NB Clomycin Cutinorm † Fourderm A † NC-Derm Neocip FC Otek-AC+ Sigmaderm Sofradex † Surfaz Surfaz-SN Translipo-Triple
Indonesia: Baycuten-N Heltiskin Lotriderm
Ireland: Canesten HC Lotriderm
Israel: Agisten with Aloe Vera Clotrisone Hydroagisten Polycutan Tevacutan Triderm
Italy: Desamix Effe Meclon
Malaysia: Baycuten N Betamethasone Go Candacort Triderm-C
Mexico: Barmicil Compuesto Baycuten N Beclogen Betrigen Clotricina Gelmicin Miclobet Prubagen Quadriderm N † Triderm Xyloderm
New Zealand: Lotricomb †
Philippines: Baycuten Candibec Clotrasone Triderm
Poland: Lotriderm Triderm
Portugal: Baycuten Beta-Micoter Flotiran Quadriderme
Russia: Akriderm GK Candibiotic Candid B Metrogyl Plus Triderm
South Africa: Lotriderm
Singapore Candacort Canesten HC Clotrasone † Combiderm Gentriderm Gentrisone Modaderm Neoderm Triderm
Spain: Beta Micoter Clotrasone
Switzerland: Imacort Imazol Triderm
Thailand: Bacda-B Canasone † Canazol-BE Candacort Clotrasone † Derzid-C Fango-B Fungicon Fungiderm-B Gynesten-B Gynestin Mycla-B Myrazole-B Twina
Turkey: Imazol
UK: Canesten HC
USA: Lotrisone
Venezuela: Baycuten N Lotricomb Lotrisone Triderm.
The symbol † denotes a preparation no longer actively marketed.
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Synonyms of Clotrimazole:
Chlotrimazole, Clotrimazol
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Therapeutic classes of Clotrimazole:
Anti-Infective Agents, Local, Antifungal Agents, Growth Inhibitors
Dosage forms of Clotrimazole:
| Form | Route | Strength |
|---|---|---|
| Cream | Intravaginal | |
| Cream | Topical |
Do I need a Prescription to buy Clotrimazole in Online Pharmasy?
No. You can purchase Clotrimazole without a prescription!
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